A physiologic in vitro model of the inferior vena cava with a computer-controlled flow system for testing of inferior vena cava filters.
A physiologic in vitro model of the inferior vena cava with a computer-controlled flow system for testing of inferior vena cava filters.
复制标题
下腔静脉的生理体外模型，具有计算机控制的流动系统，用于测试下腔静脉过滤器。
DOI：
10.1097/00004424-199709000-00003
复制
发表时间：
1997
影响因子：
6.7
通讯作者：
Klaus Mathias
中科院分区：
文献类型：
--
作者：
Horst J. Jaeger;Thomas Mair;Marius Geller;R. Kinne;A. Christmann;Klaus Mathias
依据和解释
作者开发了一种用于测试滤器的下腔静脉（IVC）体外生理模型。
方法
该模型由离心泵驱动。计算机控制的电磁阀用于产生不同的流型。在IVC闭塞的情况下，通过旁路回路实现对压力增加的限制。甘油溶液用于灌注。人工凝块是由聚丙烯酰胺凝胶制成的。数据采集包括连续监测过滤器上的流量和压差以及测试事件的视频记录。
结果
该模型可以产生恒定和脉动流。在闭塞的情况下，压力增加可以限制在70 mm Hg。可以计算IVC中的流速。介绍了血栓捕获的分类。大多数结果的检测具有重现性。
结论
体外模型模拟IVC中的生理条件。它可用于不同滤波器的对比测试和新滤波器设计的评估。
RATIONALE AND OBJECTIVES
The authors develop a physiologic in vitro model of the inferior vena cava (IVC) for testing of filters.
METHODS
The model is driven by a centrifugal pump. A computer-controlled electromagnetic valve is used for generation of different flow patterns. Limitation of the pressure increase in case of IVC occlusion is achieved by a bypass circuit. A glycerin solution is used for perfusion. Artificial clots are made from polyacrylamide gel. Data acquisition includes continuous monitoring of flow and difference pressure over the filter and video recording of the testing events.
RESULTS
The model can generate constant and pulsatile flows. The pressure increase can be limited to 70 mm Hg in case of occlusion. Calculation of the flow velocities in the IVC is possible. A classification of thrombus capturing is presented. The testing of most of the results are reproducible.
CONCLUSIONS
The in vitro model simulates the physiologic conditions in the IVC. It can be used for comparative testing of different filters and the evaluation of new filter designs.