An Mhc class I allele associated to the expression of T-dependent immune response in the house sparrow
An Mhc class I allele associated to the expression of T-dependent immune response in the house sparrow
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DOI：
10.1007/s00251-005-0046-5
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发表时间：
2005-11-01
期刊：
影响因子：
3.2
通讯作者：
Sorci, G
中科院分区：
文献类型：
--
作者：
Bonneaud, C;Richard, M;Sorci, G
主要组织相容性复合体（Mhc）编码高度可变的分子，负责识别外源抗原并随后激活宿主的免疫应答。因此，MHC多态性与病原体抗性和免疫活性相关，携带较高多样性的MHC等位基因或一个特定的MHC等位基因的个体对给定抗原表现出更强的免疫应答。Mhc等位基因和免疫活性之间的联系从未在脊椎动物的自然种群中被探索过。为了填补这一空白，我们挑战家雀（Passer arteriticus）与两个T-依赖性抗原（植物血凝素和绵羊红细胞），并研究了初级和二级免疫反应的关系，他们的MHC I类基因型。Mhc等位基因的总数对两种抗原的初级或次级应答没有影响。然而，一个特定的Mhc等位基因与对两种抗原的反应增加相关。我们的研究结果指向贡献的MHC，或其他基因的连锁不平衡与MHC，在野生动物物种的免疫反应的调节。
The major histocompatibility complex (Mhc) encodes for highly variable molecules, responsible for foreign antigen recognition and subsequent activation of immune responses in hosts. Mhc polymorphism should hence be related to pathogen resistance and immune activity, with individuals that carry either a higher diversity of Mhc alleles or one specific Mhc allele exhibiting a stronger immune response to a given antigen. Links between Mhc alleles and immune activity have never been explored in natural populations of vertebrates. To fill this gap, we challenged house sparrows (Passer domesticus) with two T-dependent antigens (phytohemagglutinin and sheep red blood cells) and examined both primary and secondary immune responses in relation to their Mhc class I genotypes. The total number of Mhc alleles had no influence on either primary or secondary response to the two antigens. One particular Mhc allele, however, was associated with an increased response to both antigens. Our results point toward a contribution of the Mhc, or of other genes in linkage disequilibrium with the Mhc, in the regulation of immune responses in a wild animal species.