The relationship between cognition, depression, fatigue, and disability in patients with multiple sclerosis
The relationship between cognition, depression, fatigue, and disability in patients with multiple sclerosis
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DOI：
10.1007/s11845-020-02377-2
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发表时间：
2020-10-01
影响因子：
2.1
通讯作者：
Ozakbas, Serkan
中科院分区：
文献类型：
--
作者：
Yigit, Pinar;Acikgoz, Ayla;Ozakbas, Serkan
多发性硬化（MS）是一种慢性、进行性、神经退行性疾病。MS通常会导致残疾、认知缺陷、疲劳和抑郁症状。目的评估多发性硬化症（MS）患者的认知功能，探讨抑郁、疲劳和残疾对认知功能的影响。方法采用多发性硬化简明国际认知评定量表（BICAMS）对200例多发性硬化患者进行评定。采用扩展残疾状态量表（EDSS）评定残疾程度。疲劳严重程度量表（FSS）和贝克抑郁量表（BDI），分别用于疲劳和抑郁水平。结果病程在5年以上者EDSS和FSS评分明显高于病程在5年以上者。EDSS >= 4的患者BICAMS表现较低，FSS评分较高。疲劳组和非疲劳组之间的符号数字模态测试（SDMT）表现有显著差异（分别为FSS >= 4和FSS < 4）。当抑郁和疲劳症状同时存在，或只存在其中之一或不存在时，SDMT表现存在显着差异。结论残疾程度和疲劳程度对老年痴呆症患者的认知功能有不良影响，抑郁对老年痴呆症患者的认知功能无明显影响。MS特异性BICAMS可有益于评估MS的认知状态。
Background Multiple sclerosis (MS) is a chronic, progressive, and neurodegenerative central nervous system disorder. MS usually causes disability, cognitive deficiency, fatigue, and depression symptoms. Objectives To assess cognitive functions of people with MS (pwMS) and investigate the impact of depression, fatigue, and disability on cognitive functions. Methods We administered the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) battery to assess 200 pwMS. The Expanded Disability Status Scale (EDSS) was used to evaluate disability levels. Fatigue Severity Scale (FSS) and the Beck Depression Inventory (BDI) were used, respectively, for fatigue and depression levels. Results EDSS and FSS scores were significantly higher in those with a disease duration of 5 years or more. Those with the EDSS >= 4 were found to have lower BICAMS performances and higher FSS scores. There was a significant difference in Symbol Digit Modalities Test (SDMT) performances between the groups with and without fatigue (FSS >= 4 and FSS < 4, respectively). When depression and fatigue symptoms concur or in the existence of just one of them or none of them, significant differences in terms of SDMT performances have been shown. Conclusion The level of disability and fatigue adversely affects the cognitive functions of pwMS; depression has no significant effect. BICAMS that is specific for MS can be beneficial to assess the cognitive state of pwMS.