15O Radioactivity clearance is faster after intracarotid bolus injection of 15O-labeled oxyhemoglobin than after 15O-water injection.
15O Radioactivity clearance is faster after intracarotid bolus injection of 15O-labeled oxyhemoglobin than after 15O-water injection.
复制标题
颈动脉内推注注射 15O 标记的氧合血红蛋白后，15O 放射性清除速度比注射 15O 水后更快。
DOI：
10.1097/01.wcb.0000071889.63724.1f
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Kanno,Iwao
中科院分区：
文献类型：
--
作者：
Seki,Chie;Kershaw,Jeff;Toussaint,Paule-Joanne;Kashikura,Kenichi;Matsuura,Tetsuya;Fujita,Hideaki;Kanno,Iwao
The authors tested the hypothesis that the oxygen content of brain tissue is negligible by injecting an intracarotid bolus of15O-labeled tracer into rats. Under the hypothesis, the clearance rates of15O radioactivity from the brain after injections of both15O-labeled water (H215O) and15O-labeled oxyhemoglobin (HbO15O) should be identical. However, the logarithmic slope of the15O radioactivity curve after HbO15O injection (0.494 ± 0.071 min-1) was steeper than that after H215O injection (0.406 ± 0.038 min−1) (P<0.001, n = 13), where the time range used in the comparison was between 60 and 120 seconds after the injection. A possible interpretation of this result is that nonmetabolized O15O may dwell in the brain tissue for a finite period of time before it is eventually metabolized or returned to the blood stream unaltered. These findings contradict assumptions made by models currently used to measure cerebral oxygen metabolism.
