Multistep and multicentric development of hepatocellular carcinoma: histological analysis of 980 resected nodules
Multistep and multicentric development of hepatocellular carcinoma: histological analysis of 980 resected nodules
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DOI：
10.1016/j.jhep.2004.10.024
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发表时间：
2005-02-01
影响因子：
25.7
通讯作者：
Sakamoto, M
中科院分区：
文献类型：
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作者：
Oikawa, T;Ojima, H;Sakamoto, M
背景/目标：组织学观察支持肝细胞癌（HCC）在慢性肝病病例中多步骤和多中心发展的概念。然而，这种方式的发展HCC和类型的背景肝脏diseases.Methods：共980 HCC结节切除664例患者的发病率之间的关系进行了分析。多步骤HCC被定义为分化良好的HCC包含汇管区（早期HCC），或在结节周围存在早期HCC样区域。在多结节病例中，如果较小的结节显示多步骤HCC的特征，或如果每个结节显示不同的组织学类型，则定义为多中心HCC。符合多步骤HCC的标准。在664例患者中，177例（26.7%）有符合多中心HCC标准的多发结节。HCV-Ab阳性组多步骤和多中心肝癌的发生率均显著高于HCV-Ag阳性组（分别为46.0 vs.19.1%，P < 0.001和34.1 vs.16.5%，P = 0.005）。(C)2004年欧洲肝脏研究协会。Elsevier B. V.出版，保留所有权利。
Background/Aims: Histological observations support the concept of multistep and multicentric development of hepatocellular carcinoma (HCC) in cases of chronic liver disease. However, the relationship between the incidence of such a modality of development of HCC and the type of background liver disease has not been fully investigated.Methods: A total of 980 HCC nodules resected from 664 patients were analyzed. Multistep HCC was defined as well differentiated HCC containing the portal tracts (early HCC), or the presence of early HCC-like areas in the periphery of the nodule. In cases with multiple nodules, if the smaller nodule showed the features of multistep HCC, or if each nodule showed a distinct histology, the case was defined to have multicentric HCC.Results: Of the 980 nodules, 369 (37.7%). met the criteria of multistep HCC. Of the 664 patients, 177 (26.7%) had multiple nodules that met the criteria of multicentric HCC. Both the incidences of multistep and multicentric HCC were significantly higher in HCV-Ab-positive cases than in HBs-Ag-positive cases (46.0 vs. 19.1%, P < 0.001 and 34.1 vs. 16.5%, P = 0.005, respectively).Conclusions: Multistep and multicentric HCC develops most frequently in patients with HCV infection. (C) 2004 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.