SELF-ASSEMBLING ORGANIC NANOTUBES BASED ON A CYCLIC PEPTIDE ARCHITECTURE
SELF-ASSEMBLING ORGANIC NANOTUBES BASED ON A CYCLIC PEPTIDE ARCHITECTURE
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DOI：
10.1038/366324a0
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发表时间：
1993-11-25
期刊：
影响因子：
64.8
通讯作者：
KHAZANOVICH, N
中科院分区：
文献类型：
--
作者：
GHADIRI, MR;GRANJA, JR;KHAZANOVICH, N
分子尺度的中空管状结构可以在化学、生物化学和材料科学中提供各种应用。同心碳纳米管1，2已经吸引了大量的关注，而分子筛的三维管状孔结构已经在工业上长期开发3 - 8。基于有机材料的纳米级管也已在之前报道9 - 13。在这里，我们报告的设计，合成和表征的一类新的有机纳米管的基础上合理设计的环状多肽。当质子化时，这些化合物结晶成数百纳米长的管状结构，内径为7 - 8埃。电子显微镜，电子衍射，傅立叶变换红外光谱和分子建模提供支持拟议的管状结构。这些管是开放式的，具有统一的形状和内径。我们预期它们在包合化学、催化、分子电子学和分子分离技术等方面可能有潜在的应用。
HOLLOW tubular structures of molecular dimensions may offer a variety of applications in chemistry, biochemistry and materials science. Concentric carbon nanotubes1,2 have attracted a great deal of attention, while the three-dimensional tubular pore structures of molecular sieves have long been exploited industrially3-8. Nanoscale tubes based on organic materials have also been reported previously9-13. Here we report the design, synthesis and characterization of a new class of organic nanotubes based on rationally designed cyclic polypeptides. When protonated, these compounds crystallize into tubular structures hundreds of nanometres long, with internal diameters of 7-8 angstrom. Support for the proposed tubular structures is provided by electron microscopy, electron diffraction, Fourier-transform infrared spectroscopy and molecular modelling. These tubes are open-ended, with uniform shape and internal diameter. We anticipate that they may have possible applications in inclusion chemistry, catalysis, molecular electronics and molecular separation technology.