Temporal dynamics and determinants of whole brain tissue volume changes during recovery from alcohol dependence
Temporal dynamics and determinants of whole brain tissue volume changes during recovery from alcohol dependence
复制标题
DOI：
10.1016/j.drugalcdep.2004.11.004
复制
发表时间：
2005-06-01
影响因子：
4.2
通讯作者：
Meyerhoff, DJ
中科院分区：
文献类型：
--
作者：
Gazdzinski, S;Durazzo, TC;Meyerhoff, DJ
酒精依赖者的脑萎缩及其部分可逆性是一种常见的神经影像学发现。我们使用了一个自动化的三维全脑磁共振成像方法（边界位移积分）在23个酒精依赖的个人，以测量时间动态的脑组织和脊髓液体积变化超过12个月的时间间隔，并检查在禁欲和非禁欲的脑组织变化率的主要决定因素。我们发现，在清醒的第一个月，大脑组织的增长速度比接下来的几个月要快。最快的体积恢复观察到在禁欲的人最大的基线脑萎缩和饮酒严重性。非禁欲个体脑容量增加的快速逆转和组织体积的变化受到禁欲和非禁欲期的持续时间以及非禁欲的新近程度的调节。年龄、酗酒家族史密度、复发严重程度、重度饮酒发作的持续时间或年龄不是脑萎缩和脑容量恢复率的主要决定因素。治疗提供者可以使用这些有形的信息来加强清醒的生物医学益处。先前对戒酒数周后的酒精依赖者进行的脑容量定量测量可能低估了慢性酒精相关脑萎缩的全部程度。(c)2004爱思唯尔爱尔兰有限公司保留所有权利。
Brain shrinkage and its partial reversibility with abstinence is a common neuroimaging finding in alcohol dependent individuals. We used an automated three-dimensional whole brain magnetic resonance imaging method (boundary shift integral) in 23 alcohol dependent individuals to measure the temporal dynamics of cerebral tissue and spinal fluid volume changes over a 12-month interval and to examine the major determinants of brain tissue change rates during abstinence and non-abstinence. We found more rapid brain tissue gain during the first month of sobriety than in the following months. The most rapid volume recovery was observed in abstinent individuals with the greatest baseline brain shrinkage and drinking severity. The rapid reversal of brain volume gains in non-abstinent individuals and tissue volume changes are modulated by duration of abstinence and non-abstinence periods, as well as recency of non-abstinence. Age, family history density of alcoholism, relapse severity, and duration or age of onset of heavy drinking were not major determinants of brain shrinkage and brain volume recovery rates. Treatment providers may use this tangible information to reinforce the biomedical benefits of sobriety. Previous quantitative measurements of brain volumes in alcohol dependent individuals performed after several weeks of abstinence likely underestimated the full extent of chronic alcohol-associated brain shrinkage. (c) 2004 Elsevier Ireland Ltd. All rights reserved.