Effect of influenza vaccination on viral replication and immune response in persons infected with human immunodeficiency virus receiving potent antiretroviral therapy
Effect of influenza vaccination on viral replication and immune response in persons infected with human immunodeficiency virus receiving potent antiretroviral therapy
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DOI：
10.1086/315260
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发表时间：
2000-02-01
影响因子：
6.4
通讯作者：
Richman, DD
中科院分区：
文献类型：
--
作者：
G端nthard, HF;Wong, JK;Richman, DD
对 19 名感染人类免疫缺陷病毒 (HIV) 的患者进行了评估，以确定三价流感疫苗是否激活 HIV 复制，这些患者通过抗逆转录病毒治疗获得了不同程度的病毒抑制。在 5 名未感染 HIV 的疫苗接种受试者中比较了体液免疫反应和 CD4(+) 淋巴细胞亚群。 11 名患者中，有 3 名血浆 HIV RNA 水平出现短暂升高（76-89 拷贝/mL），血浆 HIV RNA 水平为 50 拷贝/mL；患者中的 HIV DNA 降低
Nineteen patients infected with human immunodeficiency virus (HIV) with varying levels of viral suppression achieved with antiretroviral therapy were evaluated to determine whether trivalent influenza vaccine activated HIV replication. Humoral immune responses and CD4(+) lymphocyte subsets were compared in 5 HIV-uninfected vaccinated subjects. Transient elevations of plasma HIV RNA levels (76-89 copies/mL) appeared within 2 weeks in 3 of 11 patients with 50 copies/mL, HIV DNA decreased in patients with