Head injury as a risk factor for brain tumors in children: Results from a multicenter case-control study
Head injury as a risk factor for brain tumors in children: Results from a multicenter case-control study
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DOI：
10.1097/00001648-199609000-00006
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发表时间：
1996-09-01
期刊：
影响因子：
5.4
通讯作者：
Holly, EA
中科院分区：
文献类型：
--
作者：
Gurney, JG;PrestonMartin, S;Holly, EA
我们在一项基于人群的病例对照研究中评估了540名原发性脑肿瘤儿童和801名对照儿童发生脑肿瘤的风险与既往头部损伤的关系。与未报告头部损伤的儿童相比，先前头部损伤导致就医的儿童患脑肿瘤的风险略高[优势比(OR)=1.4；95%置信限(CL)=1.0, 1.9]。当；我们将头部损伤组限定为相对于没有头部损伤的儿童，少数意识丧失的儿童（OR=1.6; 95% CL=0.6, 3.9）或住院过夜的儿童（OR=1.7; 95% CL= 0.7, 4.6）。我们观察到脑肿瘤的发生与涉及头部或产钳分娩的出生损伤之间没有明显的关联。在少数出生损伤或产钳分娩和随后的头部损伤的儿童中，我们观察到大约两倍的风险升高。出生损伤和随后的头部损伤的患者相对于没有出生损伤和头部损伤的患者的OR为2.6 （95% CL=1.1, 6.9）。我们的研究结果仅提供了微弱的证据来支持头部损伤是儿童脑肿瘤发生的病因，尽管我们的暴露组大多数只有轻微的头部损伤。
We evaluated the risk of brain tumor occurrence in relation to previous head injury in a population-based case control study of 540 children with a primary brain tumor and 801 control children. The risk of a brain tumor among children with a previous head injury that resulted in medical attention was slightly elevated when compared with children with no re ported head injury [odds ratio (OR)=1.4; 95% confidence limits (CL)=1.0, 1.9]. This effect was stronger when;we restricted the head-injured group to the few children with loss of consciousness (OR=1.6; 95% CL=0.6, 3.9) or an overnight admission to a hospital (OR=1.7; 95% CL 0.7, 4.6), relative to those with no head injury. We observed no appreciable association between brain tumor occurrence and birth injury involving the head or a forceps delivery. Among the few children with either a birth injury or forceps delivery and a subsequent head injury, we observed approximately twofold elevations in risk. The OR was 2.6 (95% CL=1.1, 6.9) for those with a birth injury and subsequent head injury, relative to those with neither a birth injury nor head injury. Our results provide only weak evidence in support of head injury as an etiologic agent for brain tumor occurrence in children, although most of our exposed group had only mild head injury.