Haemorrhagic syndrome of Altamira.
Haemorrhagic syndrome of Altamira.
复制标题
阿尔塔米拉出血综合征。
DOI：
10.1016/s0140-6736(74)93196-1
复制
发表时间：
1974
期刊：
影响因子：
--
通讯作者：
A. H. Andrade
中科院分区：
文献类型：
--
作者：
F. Pinheiro;G. Bensabath;D. Costa;O. Maroja;Z. Lins;A. H. Andrade
自1972年1月以来，在巴西新开通的Transamazon公路沿线沿着森林地区的移民中观察到出血综合征。大多数病例发生在阿尔塔米拉周围。这种疾病的特征是局部和播散性皮肤出血，32%的患者伴有粘膜出血。血小板计数减少，出血时间延长，约半数病例血凝块收缩不良。诊断为血小板减少性紫癜。发现病例有家族聚集性，儿童比成人多。有几个人死于这种疾病。这种情况的确切病因尚不清楚。药物、营养因素和各种病毒、立克次氏体和细菌病原体似乎不涉及。流行病学和血清学证据表明，该综合征与黑蝇（Simuelae）及其叮咬有关。阿尔塔米拉地区的病例率在雨季出现大量的simulidididiazole后不久开始上升，随着旱季的临近和黑蝇的实际消失而下降。这一地区的殖民者报告说，在雨季，黑蝇会叮咬人。这种综合症在该地区的当地人中并不常见，他们中的大多数人生活在阿尔塔米拉市，在那里，simulidazole要少得多。患者对类固醇治疗反应迅速，血小板计数在几天内恢复正常。这种疾病被命名为阿尔塔米拉出血综合征。
Since January, 1972, a hæmorrhagic syndrome has been observed among immigrants living in forested areas along the newly opened Transamazon Highway in Brazil. Most cases are found around Altamira. The illness is characterised by localised and disseminated cutaneous hæmorrhages, which are associated with mucosal bleeding in 32% of patients. Platelet-counts are reduced, and there is prolonged bleeding-time and poor clot retraction in about half of the cases. The illness was diagnosed as thrombocytopenic purpura. Familial clustering of cases was found, with more children being involved than adults. A few deaths have been attributed to the disease. The precise ætiology of this condition remains obscure. Drugs, alimentary factors, and various viral, rickettsial, and bacterial pathogens do not seem to be involved. Epidemiological and serological evidence suggests that the syndrome is associated with the black-fly, Simulium, and its bite. Case-rates in the Altamira region began to rise shortly after the appearance of large numbers of simulidæ in the rainy season, and fell with the approach of the dry season and virtual disappearance of black-flies. Colonists in this area report intense black-fly biting during the rainy season. The syndrome is not seen among natives of the region, most of whom live in the city of Altamira, where simulidæ are much less common. Patients responded rapidly to steroid therapy, with platelet-counts returning to normal within a few days. The disorder has been named the hæmorrhagic syndrome of Altamira.