Effects of the peroxisomal proliferator-activated receptor-gamma agonist pioglitazone on renal and hormonal responses to salt in healthy men.
Effects of the peroxisomal proliferator-activated receptor-gamma agonist pioglitazone on renal and hormonal responses to salt in healthy men.
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过氧化物酶体增殖物激活受体-γ 激动剂吡格列酮对健康男性肾脏和激素对盐反应的影响。
DOI：
10.1210/jc.2003-031526
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
M. Burnier
中科院分区：
文献类型：
--
作者：
A. Zanchi;A. Chiolero;M. Maillard;J. Nussberger;H. Brunner;M. Burnier
格列酮作为有效的胰岛素增敏剂用于治疗2型糖尿病。然而，在高达18%的病例中，它们可以通过一种未知的机制诱导周围水肿。在这项双盲、随机、安慰剂对照、四向交叉研究中，我们对健康志愿者进行了为期6周的吡格列酮（每天45毫克）或安慰剂对低钠（LS）和高钠（HS）饮食对血压、激素、肾脏血流动力学和肾小管反应的影响。吡格列酮对盐的全身和肾脏血流动力学反应没有影响，除了增加白天心率。吡格列酮组尿钠排泄量和锂离子清除率较低，尤其是LS饮食组（P < 0.05），提示近端小管钠离子重吸收增加。吡格列酮显著提高了LS （P = 0.02）和HS （P = 0.03）日粮的血浆肾素活性。醛固酮也有类似的趋势。吡格列酮未改变心房钠素水平。大多数受试者服用吡格列酮后体重增加。吡格列酮刺激血浆肾素活性，有利于钠潴留和健康志愿者体重增加。这些影响可能导致一些用格列酮治疗的受试者出现水肿。
Glitazones are used in the treatment of type 2 diabetes as efficient insulin sensitizers. They can, however, induce peripheral edema through an unknown mechanism in up to 18% of cases. In this double-blind, randomized, placebo-controlled, four-way, cross-over study, we examined the effects of a 6-wk administration of pioglitazone (45 mg daily) or placebo on the blood pressure, hormonal, and renal hemodynamic and tubular responses to a low (LS) and a high (HS) sodium diet in healthy volunteers. Pioglitazone had no effect on the systemic and renal hemodynamic responses to salt, except for an increase in daytime heart rate. Urinary sodium excretion and lithium clearance were lower with pioglitazone, particularly with the LS diet (P < 0.05), suggesting increased sodium reabsorption at the proximal tubule. Pioglitazone significantly increased plasma renin activity with the LS (P = 0.02) and HS (P = 0.03) diets. Similar trends were observed with aldosterone. Atrial natriuretic levels did not change with pioglitazone. Body weight increased with pioglitazone in most subjects. Pioglitazone stimulates plasma renin activity and favors sodium retention and weight gain in healthy volunteers. These effects could contribute to the development of edema in some subjects treated with glitazones.
DOI：
10.1152/ajprenal.1999.277.6.f966
发表时间：
1999-12-01
影响因子：
4.2
作者：
Yang, TX;Michele, DE;Briggs, JP
通讯作者：
Briggs, JP
评估血压对钠反应的两种测试的比较。
影响因子：
3.2
作者：
Weinberger,MH;Stegner,JE;Fineberg,NS
通讯作者：
Fineberg,NS
胰岛素抵抗简单指数的重复性特征：对研究应用的影响。
DOI：
10.1210/jcem.86.11.7880
发表时间：
2001
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Mather,KJ;Hunt,AE;Steinberg,HO;Paradisi,G;Hook,G;Katz,A;Quon,MJ;Baron,AD
通讯作者：
Baron,AD