Characterization of Cortical Networks and Corticocortical Functional Connectivity Mediating Arbitrary Visuomotor Mapping
Characterization of Cortical Networks and Corticocortical Functional Connectivity Mediating Arbitrary Visuomotor Mapping
复制标题
DOI：
10.1523/jneurosci.4892-14.2015
复制
发表时间：
2015-09-16
影响因子：
5.3
通讯作者：
Jirsa, Viktor
中科院分区：
文献类型：
--
作者：
Brovelli, Andrea;Chicharro, Daniel;Jirsa, Viktor
适应性行为建立在感官输入与行动和目标的任意联系上。虽然感觉运动和联合额纹状体回路已知介导任意视觉运动映射，但潜在的皮质-皮质动力学仍然难以捉摸。在这里，我们采用一种新颖的方法，利用伽马波段神经活动来研究人类皮层网络和皮质-皮质功能连接介导任意视觉运动映射。通过将脑磁图和MRI数据与频谱分析和波束形成技术相结合，估计了所有Brodmann区域的单次试验γ -功率时间过程。采用线性相关和格兰杰因果分析来研究皮质区域之间的功能连通性。视觉运动关联的表现以感觉运动和额顶叶网络以及内侧前额叶区域的伽马-功率和功能连接的增加为特征。顶叶上区在神经网络中起驱动作用，对背侧运动前区产生格兰杰因果关系。运动前区作为顶叶到内侧前额叶皮层的中继站，在神经网络中起接收作用。Link community分析进一步表明，视觉运动映射反映了多个子网络的协调性，这些子网络在运动区和额顶叶区之间有很强的重叠。我们提出了潜在的认知过程和皮质皮质功能连接的联想帐户。总的来说，我们的方法和结果为更好地理解分布式大脑活动如何协调适应性行为提供了新的视角。
Adaptive behaviors are built on the arbitrary linkage of sensory inputs to actions and goals. Although the sensorimotor and associative frontostriatal circuits are known to mediate arbitrary visuomotor mappings, the underlying corticocortico dynamics remain elusive. Here, we take a novel approach exploiting gamma-band neural activity to study the human cortical networks and corticocortical functional connectivity mediating arbitrary visuomotor mapping. Single-trial gamma-power time courses were estimated for all Brodmann areas by combing magnetoencephalographic and MRI data with spectral analysis and beam-forming techniques. Linear correlation and Granger causality analyses were performed to investigate functional connectivity between cortical regions. The performance of visuomotor associations was characterized by an increase in gamma-power and functional connectivity over the sensorimotor and frontoparietal network, in addition to medial prefrontal areas. The superior parietal area played a driving role in the network, exerting Granger causality on the dorsal premotor area. Premotor areas acted as relay from parietal to medial prefrontal cortices, which played a receiving role in the network. Link community analysis further revealed that visuomotor mappings reflect the coordination of multiple subnetworks with strong overlap over motor and frontoparietal areas. We put forward an associative account of the underlying cognitive processes and corticocortical functional connectivity. Overall, our approach and results provide novel perspectives toward a better understanding of how distributed brain activity coordinates adaptive behaviors.