Mapping at glomerular resolution: fMRI of rat olfactory bulb
Mapping at glomerular resolution: fMRI of rat olfactory bulb
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DOI：
10.1002/mrm.10248
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发表时间：
2002-09-01
影响因子：
3.3
通讯作者：
Hyder, F
中科院分区：
文献类型：
--
作者：
Kida, I;Xu, FQ;Hyder, F
老鼠的嗅球包含大约2000个功能单位，称为肾小球，用于识别气味的特殊特征。单个肾小球的活性定位（近似于0.002穆尔）对于理解嗅觉信息编码机制具有重要意义。采用血氧水平依赖（BOLD）方法，在7 T下对大鼠嗅球进行了高分辨率功能MRI（fMRI）研究。无论是个人或集群的功能磁共振体素提示活动的嗅觉神经和肾小球层重复2分钟的曝光乙酸异戊酯在空间分辨率为0.001-0.003穆尔检测。肾小球聚集对嗅觉的重要性以及具有更高空间分辨率的BOLD映射的意义（即，远小于0.001穆尔体素）。高分辨率在体大鼠嗅球功能磁共振成像在高磁场定位有望为了解嗅觉提供新的数据。(C)2002 Wiley-Liss，Inc.
The rat olfactory bulb contains similar to2000 functional units called glomeruli which are used to recognize specific characteristics of odorants. Activity localization of individual glomerulae (similar to0.002 muL) has important consequences for understanding mechanisms in olfactory information encoding. High-resolution functional MRI (fMRI data from the rat olfactory bulb are presented using the blood oxygenation level dependent (BOLD) method at 7 T. Either individual or clusters of fMRI voxels suggestive of activity in the olfactory nerve and glomerular layers were reproducibly detected with repeated 2-min exposures of iso-amyl acetate at spatial resolution of 0.001-0.003 muL. The importance of glomerular clustering for olfaction and the implications of BOLD mapping with even higher spatial resolution (i.e., much less than0.001 muL voxels) are discussed. High-resolution in vivo mapping of the rat olfactory bulb with fMRI at high magnetic field promises to provide novel data for understanding olfaction. (C) 2002 Wiley-Liss, Inc.