Cancer stem cell metabolism.
Cancer stem cell metabolism.
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DOI：
10.1186/s13058-016-0712-6
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发表时间：
2016-05-24
期刊：
影响因子：
--
通讯作者：
Lisanti MP
中科院分区：
文献类型：
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作者：
Peiris-Pagès M;Martinez-Outschoorn UE;Pestell RG;Sotgia F;Lisanti MP
癌症现在被认为是一种干细胞疾病。关于癌症干细胞的代谢特征仍然没有达成共识，一些研究表明它们主要是糖酵解的，而其他研究则指出线粒体代谢是它们的主要能量来源。癌症干细胞似乎也通过方便地将能量生产从一种途径转移到另一种途径，或通过获得中间代谢表型，使其代谢适应微环境的变化。确定癌症干细胞代谢在癌症发生中的作用已成为癌症研究的主要焦点，并且为发现临床靶点进行了大量努力。
Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteristics of cancer stem cells, with several studies indicating that they are mainly glycolytic and others pointing instead to mitochondrial metabolism as their principal source of energy. Cancer stem cells also seem to adapt their metabolism to microenvironmental changes by conveniently shifting energy production from one pathway to another, or by acquiring intermediate metabolic phenotypes. Determining the role of cancer stem cell metabolism in carcinogenesis has become a major focus in cancer research, and substantial efforts are conducted towards discovering clinical targets.