Organochlorine levels in maternal and umbilical cord blood plasma in Arctic Canada
Organochlorine levels in maternal and umbilical cord blood plasma in Arctic Canada
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DOI：
10.1016/s0048-9697(02)00319-4
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发表时间：
2003-01-20
影响因子：
9.8
通讯作者：
Van Oostdam, J
中科院分区：
文献类型：
--
作者：
Walker, JB;Seddon, L;Van Oostdam, J
加拿大北极地区西北地区和努纳武特地区的母亲和新生儿接触有机氯和金属污染物的基线已经确定。介绍了因纽特人、德内人、梅蒂斯人、高加索人和其他非土著参与者的母亲和脐带血血浆有机氯水平。1994年5月至1999年6月期间，共有523名妇女自愿参加，并提供了知情同意书：结果收集了386份产妇血液样本、407份脐带血样本和351对产妇/脐带。近一半的参与者经常吸烟，包括77%的因纽特人参与者。本文介绍了多氯联苯（多氯联苯1260和14种同系物）和有机氯农药（包括p，p '-DDT、p，p'-DDE、乙型六氯环己烷、六氯苯、顺式和反式九氯、环氧七氯、氯氧苄、灭蚁灵、狄氏剂和毒杀芬）的母体和脐带结果。因纽特人母亲的多氯联苯水平（Aroclor 1260）平均为4.42（+/-9.03）mug/l，比Dene/Metis高3.3倍，比高加索人高3.4倍。其他非原住民组（中国人，菲律宾人，菲律宾人）的平均DDE水平高出2.8倍。东印度和多民族）比因纽特人组，分别为3.99 mug/l和1.42 mug/l。因纽特人的脐带血多氯联苯水平（Aroclor 1260）平均为1.16（+/-2.42）mug/l，比其他种族高3.3-4倍。在所有母体样本中检测到PCBs、pp '-DDE和六氯苯，在所有脐带样本中检测到pp'-DDE。回归系数的母体/脐带对选定的有机氯。本研究的其他结果，包括母体和脐带金属数据，将在其他地方介绍。(C)2002年爱思唯尔科学有限公司保留所有权利。
A baseline for exposure to organochlorine and metal contaminants has been established for mothers and newborns in the Northwest Territories and Nunavut areas of Arctic Canada. Maternal and umbilical cord blood plasma organochlorine levels are described for Inuit, Dene, Metis, Caucasian and Other non-Aboriginal participants. Overall 523 women volunteered to participate by giving their written informed consent between May 1994 and June 1999: resulting in the collection of 386 maternal blood samples, 407 cord blood samples and 351 maternal/cord pairs. Nearly half of all the participants regularly smoked cigarettes, including 77% of the Inuit participants. Maternal and cord results are presented for PCBs (as Aroclor 1260 and 14 congeners) and organochlorine pesticides, including p,p'-DDT, p,p'-DDE, beta-hexachlorocyclohexane (beta-HCH), hexachlorobenzene (HCB), cis and trans nonachlor, heptachlor epoxide, oxychlordane, mirex, dieldrin and toxaphene. Maternal PCB levels (as Aroclor 1260) averaged 4.42 (+/-9.03) mug/l in Inuit, which was 3.3 times higher than those found in Dene/Metis, and 3.4 times higher than levels in Caucasians. Mean DDE levels were 2.8 times higher in the Other non-Aboriginal group (Chinese, Filipino,. East Indian and multiple ethnicity) than in the Inuit group, at 3.99 mug/l and 1.42 mug/l, respectively. Cord blood PCB levels (as Aroclor 1260) averaged 1.16 (+/-2.42) mug/l for Inuit participants, which was 3.3-4 fold higher than the other ethnic groups. PCBs, pp'-DDE and hexachlorobenzene were detected in all maternal samples, and pp'-DDE was detected in all cord samples. Regression coefficients for maternal/cord pairs are presented for selected organochlorines. Other results from this study, including maternal and cord metals data, will be presented elsewhere. (C) 2002 Elsevier Science B.V. All fights reserved.