Oral Mucosa Tissue Response to Titanium Cover Screws
Oral Mucosa Tissue Response to Titanium Cover Screws
复制标题
DOI：
10.1902/jop.2011.110392
复制
发表时间：
2012-08-01
影响因子：
4.3
通讯作者：
Cabrini, Romulo L.
中科院分区：
文献类型：
--
作者：
Olmedo, Daniel G.;Paparella, Maria L.;Cabrini, Romulo L.
背景：钛是牙科种植学中应用最广泛的金属。颗粒从金属结构释放到生物环境中可能是插入、基台连接或取出失败植入物期间电化学过程（腐蚀）和/或机械破坏的结果。本研究的目的是评估钛覆盖screws.Methods：一百五十三个活检的种植体上的口腔粘膜邻近的覆盖螺钉的埋入式牙种植体邻近的组织反应。进行组织学研究，以分析上皮和结缔组织以及金属颗粒的存在，这是确定使用微量化学分析。应用免疫组化技术对朗格汉斯细胞、巨噬细胞和T淋巴细胞进行了研究。结果：41%的粘膜活检组织在切片厚度的不同层中显示出金属颗粒。颗粒数量和大小在样品之间变化很大。免疫组织化学研究证实了与金属颗粒相关的巨噬细胞和T淋巴细胞的存在。微量化学分析表明，颗粒中存在钛。在SEM分析，螺钉的表面表现出凹陷和irregulars.Conclusions：在粘膜中看到的生物效应与盖螺钉接触可能与钛或其他元素，如铝或钒的存在。应进一步研究颗粒对金属器械附近软组织的潜在长期生物学效应，因为这些效应可能影响植入物的临床结局。牙周病学杂志2012;83：973-980。
Background: Titanium is the most widely used metal in dental implantology. The release of particles from metal structures into the biologic milieu may be the result of electrochemical processes (corrosion) and/or mechanical disruption during insertion, abutment connection, or removal of failing implants. The aim of the present study is to evaluate tissue response of human oral mucosa adjacent to titanium cover screws.Methods: One hundred fifty-three biopsies of the supra-implant oral mucosa adjacent to the cover screw of submerged dental implants were analyzed. Histologic studies were performed to analyze epithelial and connective tissue as well as the presence of metal particles, which were identified using microchemical analysis. Langerhans cells, macrophages, and T lymphocytes were studied using immunohistochemical techniques. The surface of the cover screws was evaluated by scanning electron microscopy (SEM).Results: Forty-one percent of mucosa biopsies exhibited metal particles in different layers of the section thickness. Particle number and size varied greatly among specimens. Immunohistochemical study confirmed the presence of macrophages and T lymphocytes associated with the metal particles. Microchemical analysis revealed the presence of titanium in the particles. On SEM analysis, the surface of the screws exhibited depressions and irregularities.Conclusions: The biologic effects seen in the mucosa in contact with the cover screws might be associated with the presence of titanium or other elements, such as aluminum or vanadium. The potential long-term biologic effects of particles on soft tissues adjacent to metallic devices should be further investigated because these effects might affect the clinical outcome of the implant. J Periodontol 2012;83:973-980.