Alcohol drinking and colorectal cancer in Japanese: A pooled analysis of results from five cohort studies
Alcohol drinking and colorectal cancer in Japanese: A pooled analysis of results from five cohort studies
复制标题
DOI：
10.1093/aje/kwn073
复制
发表时间：
2008-06-15
影响因子：
5
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
--
作者：
Mizoue, Tetsuya;Inoue, Manami;Tsugane, Shoichiro
结直肠癌是一种与酒精相关的恶性肿瘤;然而，在亚洲人群中，这种相关性似乎更强，慢代谢醛脱氢酶变异体的患病率相对较高。为了研究日本人饮酒与结直肠癌之间的关系，作者分析了五项队列研究的原始数据，这些研究使用基线时经过验证的问卷测量了酒精摄入量。在个体研究中计算风险比，并对一组常见的变量进行调整，然后使用随机效应模型进行组合。在2，231，010人年的随访期间（从1988年到2004年不等），确定了2，802例结直肠癌病例。在男性中，与不饮酒相比，酒精摄入量为23-45.9克/天、46-68.9克/天、69-91.9克/天和>= 92克/天的多变量校正合并风险比为1.42（95%置信区间（CI）：1.21，1.66）、1.95（95% CI：1.53，2.49）、2.15（95% CI：1.74，2.64）和2.96（95% CI：2.27，3.86）（趋势p < 0.001）。结肠和直肠的相关性都很明显。在女性中也观察到了显著的正相关。四分之一的男性结直肠癌病例可归因于酒精摄入量≥ 23克/天。酒精与结直肠癌的关联在日本人中似乎比在西方人群中更明显。这种差异是否可以归因于遗传或环境因素需要澄清。
Colorectal cancer is an alcohol-related malignancy; however, the association appears to be stronger among Asian populations with a relatively high prevalence of the slow-metabolizing aldehyde dehydrogenase variant. To examine the association between alcohol consumption and colorectal cancer in Japanese, the authors analyzed original data from five cohort studies that measured alcohol intake using validated questionnaires at baseline. Hazard ratios were calculated in the individual studies, with adjustment for a common set of variables, and then combined using a random-effects model. During 2,231,010 person-years of follow-up (ranging variously from 1988 to 2004), 2,802 colorectal cancer cases were identified. In men, multivariate-adjusted pooled hazard ratios for alcohol intakes of 23-45.9 g/day, 46-68.9 g/day, 69-91.9 g/day, and >= 92 g/day, compared with nondrinking, were 1.42 (95% confidence interval (CI): 1.21, 1.66), 1.95 (95% CI: 1.53, 2.49), 2.15 (95% CI: 1.74, 2.64), and 2.96 (95% CI: 2.27, 3.86), respectively (p for trend < 0.001). The association was evident for both the colon and the rectum. A significant positive association was also observed in women. One fourth of colorectal cancer cases in men were attributable to an alcohol intake of >= 23 g/day. An alcohol-colorectal cancer association seems to be more apparent in Japanese than in Western populations. Whether this difference can be ascribed to genetic or environmental factors needs to be clarified.