Simulation study of breast tissue hemodynamics during pressure perturbation.
Simulation study of breast tissue hemodynamics during pressure perturbation.
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DOI：
10.1007/0-387-26206-7_3
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发表时间：
2005
影响因子：
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通讯作者：
S. Nioka;S. Wen;Jun Zhang;Juan Du;Xavior Intes;Zhongyao Zhao;B. Chance
中科院分区：
文献类型：
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作者：
S. Nioka;S. Wen;Jun Zhang;Juan Du;Xavior Intes;Zhongyao Zhao;B. Chance
我们模拟了压迫乳房对血容量和组织氧合的影响。我们试图回答这个问题：乳房检查期间的压迫如何影响乳房组织的循环系统，即血流、血池和氧浓度？我们假设血液分布在两个腔室，动脉和静脉。所有参数均用氧合血红蛋白和脱氧血红蛋白的量表示，并采用非侵入性方法近红外光谱（NIRS）进行测量。模拟数据显示，当用10 cm直径探头（或78 cm 2）在100 cm H2O下挤压乳房时，由于动脉流量较低和静脉流出量较高，乳房中的血容量池减少。当压力释放时，血容量逆转。乳腺静脉血氧饱和度下降，但总体组织饱和度（呈现NIRS信号，体积加权平均饱和度）增加。结果表明，仿真可以用来获得静脉和平均血氧饱和度以及血液流量在压缩的乳房组织。
We simulated the effects of compression of the breast on blood volume and tissue oxygenation. We sought to answer the question: how does the compression during breast examination impact on the circulatory systems of the breast tissue, namely blood flow, blood pooling, and oxygen concentration? We assumed that the blood was distributed in two compartments, arterial and venous. All the parameters were expressed with oxy- and deoxyhemoglobin quantities and were measured with a non-invasive method, Near Infrared Spectroscopy (NIRS). The simulated data showed that the blood volume pool in the breast decreased due to lower arterial flow and higher venous outflow, as the breast was squeezed under 100 cm H2O with a 10 cm diameter probe (or 78 cm2). The blood volume was reversed when the pressure was released. The breast venous oxygen saturation dropped, but overall tissue saturation (presenting NIRS signal, volume weighted average saturation) was increased. The results showed that simulation can be used to obtain venous and average oxygen saturation as well as blood flow in compressed breast tissues.