Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell Transplantaion
Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell Transplantaion
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DOI：
10.1056/nejmoa0802905
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发表时间：
2009-02-12
影响因子：
158.5
通讯作者：
Thiel, Eckhard
中科院分区：
文献类型：
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作者：
Huetter, Gero;Nowak, Daniel;Thiel, Eckhard
感染人类免疫缺陷病毒1型（HIV-1）需要CD4受体和趋化因子受体的存在，主要是趋化因子5 （CCR5）。CCR5等位基因32 bp缺失的纯合性提供了对HIV-1获得的抗性。我们将来自一名CCR5 delta32纯合子供体的干细胞移植给一名急性髓性白血病和HIV-1感染患者。患者在移植和停止抗逆转录病毒治疗后20个月仍未出现病毒反弹。这一结果表明CCR5在维持HIV-1感染中发挥着关键作用。
Infection with the human immunodeficiency virus type 1 (HIV-1) requires the presence of a CD4 receptor and a chemokine receptor, principally chemokine 5 (CCR5). Homozygosity for a 32-bp deletion in the CCR5 allele provides resistance against HIV-1 acquisition. We transplanted stem cells from a donor who was homozygous for CCR5 delta32 in a patient with acute myeloid leukemia and HIV-1 infection. The patient remained without viral rebound 20 months after transplantation and discontinuation of antiretroviral therapy. This outcome demonstrates the critical role CCR5 plays in maintaining HIV-1 infection.