Risk factors associated with severity of eosinophilic otitis media.
Risk factors associated with severity of eosinophilic otitis media.
复制标题
与嗜酸粒细胞性中耳炎严重程度相关的危险因素。
DOI：
10.1016/j.anl.2014.08.003
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发表时间：
2014
影响因子：
1.7
通讯作者：
Iino Y.
中科院分区：
文献类型：
--
作者：
Kanazawa H;Yoshida N;Yamamoto H;Hara M;Hasegawa M;Matsuzawa S;Shinnabe A;Iino Y.
嗜酸性中耳炎（EOM）是一种与支气管哮喘相关的顽固性中耳炎。EOM的临床特征是明显的，但可能发生严重的EOM，对正在进行的治疗无反应。本研究的目的是探讨与EOM的严重程度相关的潜在危险因素。MethodsWe评分的EOM严重程度的26例患者根据中耳积液（中耳积液），中耳粘膜厚度，局部和口服皮质类固醇的使用，并使用抗生素，所有测量超过3个月的时间。对4个3个月（1年）的评分取平均值。我们通过部分回归分析了临床变量的患病率：性别、年龄、体重指数（BMI）、支气管哮喘的持续时间、阿司匹林不耐受性哮喘的相关性、鼻窦炎的Lund-Mackay评分、乳突骨化、鼓室口骨性咽鼓管宽度、外周血嗜酸性粒细胞和免疫球蛋白E的百分比以及过敏性鼻炎的相关性。支气管哮喘的病程定义为从支气管哮喘发作到首次就诊年龄的时间。细菌culture.ResultsThe平均严重程度评分为6.6（出16）。病原体阳性组的严重程度评分显著高于病原体阴性组（P< 0.05）。赛季之间的得分没有显著差异。多元线性回归分析显示，BMI和支气管哮喘病程显著影响EOM严重程度评分（p< 0.05）。阿司匹林不耐受性哮喘的存在往往与严重程度评分相关。Lund-Mackay评分与肥胖呈负相关。结论EOM的严重程度与肥胖、支气管哮喘病程有显著相关性。
ObjectiveEosinophilic otitis media (EOM) is an intractable otitis media associated with bronchial asthma. Clinical characteristics of EOM are apparent, but severe EOM, which is unresponsive to ongoing treatments, can occur. The present study aimed to investigate potential risk factors associated with the severity of EOM.MethodsWe scored the EOM severity of 26 patients according to quantity of middle ear effusion (MEE), thickness of the middle ear mucosa, use of topical and oral corticosteroids, and use of antibiotics, all measured over a 3-month period. The scores for four 3-month periods (1 year) were averaged. We analyzed the prevalence of clinical variables by partial regression: sex, age, body mass index (BMI), duration of bronchial asthma, association of aspirin-intolerant asthma, Lund–Mackay score for sinusitis, mastoid pneumatization, width of the bony Eustachian tube at the tympanic orifice, percentage of eosinophils and immunoglobulin E in peripheral blood, and association of allergic rhinitis. Duration of bronchial asthma was defined as the period from onset of bronchial asthma to the age of first consultation at our hospital. Samples of MEE were taken for bacterial culture.ResultsThe average severity score was 6.6 (out of 16). The severity score in the pathogen-positive MEE group was significantly higher than that in the pathogen-negative MEE group (p< 0.05). The score was not significantly different between the seasons. Linear multiple regression analysis showed that BMI and the duration of bronchial asthma significantly affected the EOM severity score (p< 0.05). The presence of aspirin intolerant asthma tended to be correlated with the severity score. The Lund–Mackay score tended to be negatively correlated with it.ConclusionsThere is a significant association between the severity of EOM and obesity, as well as with the duration of bronchial asthma.