Biotinylated Cubosomes: A Versatile Tool for Active Targeting and Code livery of Paclitaxel and a Fluorescein-Based Lipid Dye
Biotinylated Cubosomes: A Versatile Tool for Active Targeting and Code livery of Paclitaxel and a Fluorescein-Based Lipid Dye
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DOI：
10.1021/acs.langmuir.5b03469
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发表时间：
2015-11-24
期刊：
影响因子：
3.9
通讯作者：
Landau, Ehud M.
中科院分区：
文献类型：
--
作者：
Aleandri, Simone;Bandera, Davide;Landau, Ehud M.
本文报道了用生物素官能化立方体作为制备能够主动靶向由癌细胞（过）表达的特异性受体的药物递送系统的替代方法。我们描述的设计，合成，组装和表征这些新的立方纳米粒子的小角X射线散射（SAXS）和动态激光光散射（DLS），并显示其应用于人类腺癌细胞系HeLa。这些立方体是稳定的和功能化的一种新的，设计的生物素为基础的嵌段共聚物，并能够同时运输紫杉醇，一种有效的抗癌药物，和一种疏水性荧光染料在癌细胞的主动靶向。这种生物素化的立方体可能适用于诊断、药物递送和监测针对癌细胞的主动靶向的治疗反应。
The functionalization of cubosomes with biotin is reported here as an alternative method for the preparation of drug delivery systems capable of active targeting specific receptors that are (over)expressed by cancer cells. We describe the design, synthesis, assembly, and characterization of these novel cubosome nanoparticles by small-angle X-ray scattering (SAXS) and dynamic laser light scattering (DLS) and show their application to human adenocarcinoma cell line HeLa. These cubosomes are stabilized and functionalized with a novel, designed biotin-based block copolymer and are able to simultaneously transport paclitaxel, a potent anticancer drug, and a hydrophobic fluorescent dye in the active targeting of cancer cells. Such biotinylated cubosomes are potentially applicable in diagnosis, drug delivery, and monitoring of the therapeutic response for active targeting versus cancer cells.