Sarcopenia in chronic kidney disease on conservative therapy: prevalence and association with mortality
Sarcopenia in chronic kidney disease on conservative therapy: prevalence and association with mortality
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DOI：
10.1093/ndt/gfv133
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发表时间：
2015-10-01
影响因子：
6.1
通讯作者：
Kamimura, Maria A.
中科院分区：
文献类型：
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作者：
Pereira, Rassa A.;Cordeiro, Antonio C.;Kamimura, Maria A.
背景资料。在慢性肾脏病(CKD)中，多种代谢和营养异常导致骨骼肌质量和功能的损害，从而使患者容易出现骨质疏松症。在这里，我们调查了三种不同方法定义的非透析依赖(NDD)CKD患者的骨量减少的患病率和死亡率预测能力。我们评估了287名3-5期的NDD-CKD患者[59.9+/-10.5岁；62%男性；49%糖尿病患者；肾小球滤过率(GFR)25.0+/-15.8毫升/分钟/1.73米(2)]。肌萎缩症被定义为通过握力(HGS)评估肌肉功能减退
Background. In chronic kidney disease (CKD), multiple metabolic and nutritional abnormalities contribute to the impairment of skeletal muscle mass and function thus predisposing patients to the condition of sarcopenia. Herein, we investigated the prevalence and mortality predictive power of sarcopenia, defined by three different methods, in non-dialysis-dependent (NDD) CKD patients.Methods. We evaluated 287 NDD-CKD patients in stages 3-5 [59.9 +/- 10.5 years; 62% men; 49% diabetics; glomerular filtration rate (GFR) 25.0 +/- 15.8 mL/min/1.73 m(2)]. Sarcopenia was defined as reduced muscle function assessed by handgrip strength (HGS