Four-Component Domino Reaction Leading to Multifunctionalized Quinazolines
Four-Component Domino Reaction Leading to Multifunctionalized Quinazolines
复制标题
四组分多米诺骨牌反应产生多功能喹唑啉
DOI：
10.1021/ja904011s
复制
发表时间：
2009-08-26
影响因子：
15
通讯作者：
Li, Guigen
中科院分区：
文献类型：
--
作者：
Jiang, Bo;Tu, Shu-Jiang;Li, Guigen
发现了一种新的四组分多米诺反应。该反应简单易行，只需将四种常用的反应物与K_2CO_3在乙二醇中混合，在微波辐射下进行。反应进行迅速，可在10-24分钟内完成，水作为主要副产物，使得后处理方便。四个立体异构中心与一个季碳-氨基功能控制得很好，立体化学是明确确定的X-射线结构分析。所得到的吡啶并[3，4-i]喹唑啉衍生物在有机和医药研究中具有重要意义。
A new four-component domino reaction has been discovered. The reaction is easy to perform simply by mixing four common reactants and K2CO3 in ethylene glycol under microwave irradiation. The reaction proceeds rapidly and can be finished within 10-24 min with water as the major byproduct, making workup convenient. Four stereogenic centers with one quaternary carbon-amino function are controlled very well; the stereochemistry was unequivocally determined by X-ray structural analysis. The resulting pyrido[3,4-i]quinazoline derivatives are of importance for organic and medicinal research.