COMPUTERIZED QUANTIFICATION OF ULTRASONIC HETEROGENEITY IN THYROID NODULES
COMPUTERIZED QUANTIFICATION OF ULTRASONIC HETEROGENEITY IN THYROID NODULES
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DOI：
10.1016/j.ultrasmedbio.2014.06.009
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发表时间：
2014-11-01
影响因子：
2.9
通讯作者：
Chang, King-Jen
中科院分区：
文献类型：
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作者：
Chen, Kuen-Yuan;Chen, Chiung-Nien;Chang, King-Jen
为了测试超声异质性的计算机量化是否有助于甲状腺恶性肿瘤的诊断，我们在前瞻性设置中使用客观定量的计算机化方法评估超声异质性。共400例，其中良性甲状腺结节271例，恶性甲状腺结节129例。我们收集了患者的临床资料，并由甲状腺专科医生回顾性回顾了传统灰度超声图像的异质性分级。超声非均质性（非均质指数，HI）的定量是用本文提出的方法实现的专有程序进行的。通过细针穿刺和手术病理结果诊断的良恶性结节的HI值差异显著（p < 0.001，曲线下面积= 0.714）。这些样本的超声异质性，由经验丰富的临床医生评估，不能明显区分良性和恶性甲状腺结节。然而，超声非均匀性结节的HI值高于均匀结节。这些结果表明，评价甲状腺结节超声非均匀性的计算机辅助诊断方法是一种客观、定量的方法，与常规超声非均匀性评估相关，但能更好地辅助甲状腺恶性肿瘤的诊断。(C) 2014年世界超声医学与生物学联合会。
To test whether computerized quantification of ultrasonic heterogeneity can be of help in the diagnosis of thyroid malignancy, we evaluated ultrasonic heterogeneity with an objective and quantitative computerized method in a prospective setting. A total of 400 nodules including 271 benign thyroid nodules and 129 malignant thyroid nodules were evaluated. Patient clinical data were collected, and the grading of heterogeneity on conventional gray-scale ultrasound images was retrospectively reviewed by a thyroid specialist. Quantification of ultrasonic heterogeneity (heterogeneity index, HI) was performed by a proprietary program implemented with methods proposed in this article. HI values differed significantly between benign and malignant nodules, diagnosed by a combination of fine-needle aspiration and surgical pathology results (p < 0.001, area under the curve = 0.714). The ultrasonic heterogeneity of these samples, as assessed by an experienced clinician, could not significantly differentiate between benign and malignant thyroid nodules. However, nodules with marked ultrasonic heterogeneity had higher HI values than nodules with homogeneous nodules. These results indicate that the new computer-aided diagnosis method for evaluation of the ultrasonic heterogeneity of thyroid nodules is an objective and quantitative method that is correlated with conventional ultrasonic heterogeneity assessment, but can better aid in the diagnosis of thyroid malignancy. (C) 2014 World Federation for Ultrasound in Medicine & Biology.