AN EPIDEMIC OF INFECTIONS DUE TO CHLAMYDIA-PNEUMONIAE IN MILITARY CONSCRIPTS
AN EPIDEMIC OF INFECTIONS DUE TO CHLAMYDIA-PNEUMONIAE IN MILITARY CONSCRIPTS
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DOI：
10.1093/clinids/17.3.420
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发表时间：
1993-09-01
影响因子：
11.8
通讯作者：
SAIKKU, P
中科院分区：
文献类型：
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作者：
EKMAN, MR;GRAYSTON, JT;SAIKKU, P
一项前瞻性观察性研究的流行感染肺炎衣原体菌株TWAR在芬兰军事学员提供了新的信息免疫感染后，临床综合征和并发症的范围，和细胞培养分离。一半的学员研究（43 86）有肺炎衣原体感染的实验室证据。肺炎病例和急性呼吸道疾病门诊就诊的急剧增加以及实验室感染证据沿着，加强了肺炎衣原体与疾病的病原学关联。血清学反应的模式表明，23名学员有一个原发性TWAR感染和20个有再感染。既往感染改变疾病的证据包括住院频率（12例原发感染vs. 1例再感染）、肺炎发展（10 vs. 0）和需要重复抗生素治疗（13个疗程vs. 0）。HL细胞（n = 25）中的分离频率高于HeLa 229细胞（n = 10）。
A prospective observational study of an epidemic of infection due to Chlamydia pneumoniae strain TWAR in Finnish military trainees provided new information on immunity following infection, the range of clinical syndromes and complications, and cell culture isolation. One-half of the trainees studied (43 of 86) had laboratory evidence of C pneumoniae infection. The etiologic association of C pneumoniae with disease was strengthened by the sharp increase in cases of pneumonia and in outpatient visits for acute respiratory disease along with the laboratory evidence of infection. The pattern of serological response suggested that 23 of the trainees had a primary TWAR infection and 20 had a reinfection. Evidence that prior infection modified the illness included the frequency of hospitalization (12 with primary infections vs. 1 with reinfection), the development of pneumonia (10 vs. 0), and the requirement for repeated courses of antibiotic therapy (13 courses vs. 0). Isolation was more frequent in HL cells (n = 25) than in HeLa 229 cells (n = 10).