Increasing oxygen tension improves filtration of sickle trait donor blood
Increasing oxygen tension improves filtration of sickle trait donor blood
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DOI：
10.1046/j.1365-2141.2003.04464.x
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发表时间：
2003-08-01
影响因子：
6.5
通讯作者：
Stroncek, DF
中科院分区：
文献类型：
--
作者：
Byrne, KM;Leitman, SF;Stroncek, DF
来自具有镰状细胞性状（HbAS）的供体的红细胞（RBC）组分的过滤器失效的主要原因是血红蛋白的聚合。评估了储存在各种塑料和不同体积空气中的血液的氧饱和度（sO（2））。收集10名HbAS捐献者的血液并分成两个袋，一个袋中添加空气，一个袋中不添加空气。添加空气的袋子增加了sO（2）水平（从49 +/- 10%到76 +/- 6%）。有空气的10个组件中有9个成功过滤，没有空气的10个组件中有1个成功过滤。当sO（2）增加时，RBC成分的成功过滤发生。
A major cause of filter failure of red cell (RBC) components from donors with sickle cell trait (HbAS) is the polymerization of haemoglobin. The oxygen saturation (sO(2) ) of blood stored in various plastics and different volumes of air was assessed. Blood from 10 HbAS donors was collected and divided into two bags, one with air added, one without. Bags with added air had increased sO(2) levels (from 49 +/- 10% to 76 +/- 6%). Filtration was successful for nine of 10 components with air, and one of 10 without air. Successful filtration of RBC components occurs when sO(2) is increased.