Cocaine dependence with and without PTSD among subjects in the National Institute on Drug Abuse Collaborative Cocaine Treatment Study.
Cocaine dependence with and without PTSD among subjects in the National Institute on Drug Abuse Collaborative Cocaine Treatment Study.
复制标题
国家药物滥用研究所合作可卡因治疗研究中受试者的可卡因依赖（伴或不伴 PTSD）。
DOI：
10.1176/ajp.155.2.214
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Weiss,RD
中科院分区：
文献类型：
--
作者：
Najavits,LM;Gastfriend,DR;Barber,JP;Reif,S;Muenz,LR;Blaine,J;Frank,A;Crits-Christoph,P;Thase,M;Weiss,RD
CAPTIVEThis study examined the prevalence of lifetime traumatic events and current symptoms of posttraumatic stress disorder（PTSD）among treatment-seeking cocaine dependent outpatients and compared patients with and without PTSD on current substance use，psychopathology，and sociodemographic characteristics.METHODThe subjects were 122 adult cocaine dependent outpatients participating in a treatment outcome study of psychosocial therapy.除了标准的自我报告和访谈措施的精神病理学和物质使用，受试者完成了创伤史问卷和PTSD检查表进入treatment. WITTSThese患者经历了大量的终身创伤事件（平均值=5.7），男性经历了更多的一般灾难和犯罪相关的创伤比女性，女性经历了更多的身体和性虐待比男性。根据自我报告的措施，20.5%的受试者目前符合DSM-III-R标准的创伤后应激障碍;创伤后应激障碍的比率是30.2%的女性和15.2%的男性。PTSD患者与非PTSD患者相比，同时发生轴I和轴II障碍、人际关系问题、医疗问题、治疗抵抗和精神病理学症状的比率显著较高。精神病理学症状代表了两组之间最一致的差异，并在logistic回归中提供了PTSD状态的最佳预测。然而，在目前的物质使用或社会人口学特征没有显着差异。CONCLUSION这些研究结果强调筛选物质滥用者的PTSD的价值，因为它可以确定一个小的，但大量的谁可能需要额外的治疗。似乎有必要对创伤后应激障碍与药物滥用之间的关系进行进一步研究。(Am J Psychiatry 1998; 155：214-219）
OBJECTIVEThis study examined the prevalence of lifetime traumatic events and current symptoms of posttraumatic stress disorder (PTSD) among treatment-seeking cocaine-dependent outpatients and compared patients with and without PTSD on current substance use, psychopathology, and sociodemographic characteristics.METHODThe subjects were 122 adult cocaine-dependent outpatients participating in a treatment outcome study of psychosocial therapy. In addition to standard self-report and interview measures of psychopathology and substance use, the subjects completed the Trauma History Questionnaire and the PTSD Checklist before entering treatment.RESULTSThese patients experienced a large number of lifetime traumatic events (mean=5.7); men experienced more general disasters and crime-related traumas than women, and women experienced more physical and sexual abuse than men. According to self-report measures, 20.5% of the subjects currently met the DSM-III-R criteria for PTSD; the rate of PTSD was 30.2% among women and 15.2% among men. Patients with PTSD had significantly higher rates of co-occurring axis I and axis II disorders, interpersonal problems, medical problems, resistance to treatment, and psychopathology symptoms than patients without PTSD. Psychopathology symptoms represented the most consistent difference between the two groups and provided the best prediction of PTSD status in a logistic regression. However, the groups did not differ significantly in current substance use or sociodemographic characteristics.CONCLUSIONSThese findings underscore the value of screening substance abusers for PTSD, because it can identify a small but substantial number who might require additional treatment. Further studies of the relationship between PTSD and substance abuse appear warranted. (Am J Psychiatry 1998; 155:214–219)