Non-invasive brain stimulation to investigate language production in healthy speakers: A meta-analysis
Non-invasive brain stimulation to investigate language production in healthy speakers: A meta-analysis
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DOI：
10.1016/j.bandc.2018.02.007
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发表时间：
2018-06-01
影响因子：
2.5
通讯作者：
Schutter, Dennis J. L. G.
中科院分区：
文献类型：
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作者：
Klaus, Jana;Schutter, Dennis J. L. G.
无创脑刺激已成为研究大脑和语言功能相互关系的常用方法。这项荟萃分析考察了经颅磁刺激(TMS)和直流电刺激(TDC)在研究健康志愿者语言产生方面的效果。Meta分析了30项研究中的45个效应大小，这些研究考察了NIBS对健康参与者的图片命名或语言流畅性的影响。进一步的子分析研究了刺激类型、控制、目标位置、任务、在线与离线应用以及目标电极的电流密度的潜在影响。随机效应模型显示，NIBs对语言产生的影响很小，但很可靠。随后的分析表明，与tdcs研究相比，tms的加权平均效应大小更大。在其他子分析中没有观察到统计学差异。我们得出结论，NIBS对于研究健康志愿者的语言产生是一种有用的神经科学方法。
Non-invasive brain stimulation (NIBS) has become a common method to study the interrelations between the brain and language functioning. This meta-analysis examined the efficacy of transcranial magnetic stimulation (TMS) and direct current stimulation (tDCS) in the study of language production in healthy volunteers. Forty-five effect sizes from 30 studies which investigated the effects of NIBS on picture naming or verbal fluency in healthy participants were meta-analysed. Further sub-analyses investigated potential influences of stimulation type, control, target site, task, online vs. offline application, and current density of the target electrode. Random effects modelling showed a small, but reliable effect of NIBS on language production. Subsequent analyses indicated larger weighted mean effect sizes for TMS as compared to tDCS studies. No statistical differences for the other sub-analyses were observed. We conclude that NIBS is a useful method for neuroscientific studies on language production in healthy volunteers.