High Serum FABP4 Levels are Negatively Associated with the Reversion from Prediabetes to Normal Glucose Tolerance: A 2-Year Retrospective Cohort Community Study.
High Serum FABP4 Levels are Negatively Associated with the Reversion from Prediabetes to Normal Glucose Tolerance: A 2-Year Retrospective Cohort Community Study.
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高血清 FABP4 水平与从糖尿病前期恢复到正常糖耐量呈负相关：一项为期 2 年的回顾性队列社区研究
DOI：
10.2147/dmso.s374912
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发表时间：
2022
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目的探讨脂肪酸结合蛋白4(FABP4)水平与糖尿病前期向正常糖耐量(NGT)逆转的关系。方法对398名资料完整的受试者进行为期两年的回顾性队列研究。经过2年的随访，这398名参与者被分为NGT组和糖代谢异常(AGM)组。测定FABP4的基线水平，并用非条件Logistic回归模型研究FABP4在预测糖尿病前期向NGT逆转中的作用。结果在两年的随访期内，37.4%(149/398)的受试者从糖尿病前期转为NGT。AGM患者的FABP4基线水平高于NGT患者。FABP4基线水平与糖尿病前期向NGT的逆转呈显著负相关。在调整了年龄、性别、体重指数和腰臀比后，基线时空腹血糖[优势比(OR)0.336，95%可信区间(CI)(0.196-0.576)]、服药后2小时血糖[OR 0.697，95%CI(0.581-0.837)]和FABP4[OR 0.960，95%CI(0.928-0.993)]是糖尿病前期向NGT逆转的显著独立预测因素。FABP_4受试者工作特征曲线的曲线下面积(AUC值)为0.605(95%CI：0.546~0.665)，FABP_4合并空腹血糖和餐后2小时血糖的AUC值为0.716(95%CI：0.663~0.769)。结论FABP4水平升高与糖尿病危险因素呈正相关，与糖尿病前期向NGT逆转呈负相关。FABP4、FBG、2hBG是糖尿病前期向NGT逆转的预测因子。
Objective To explore the relationship between the level of fatty acid-binding protein 4 (FABP4) and reversion from prediabetes to normal glucose tolerance (NGT). Methods A two-year retrospective cohort study was conducted on 398 participants with complete information. These 398 participants were divided into an NGT group and an abnormal glucose metabolism (AGM) group after 2 years of follow-up. The baseline level of FABP4 was determined, and the role of FABP4 in predicting reversion from prediabetes to NGT was investigated using an unconditional logistic regression model. Results Over the two-year follow-up period, 37.4% (149/398) of the participants reverted from prediabetes to NGT. The participants with AGM had a higher baseline level of FABP4 than those with NGT. The baseline level of FABP4 was significantly negatively correlated with reversion from prediabetes to NGT. After adjusting for age, sex, body mass index and waist-to-hip ratio, the level of fasting blood glucose (FBG) [odds ratio (OR) 0.336, 95% confidence interval (CI) (0.196–0.576)], 2-h post-challenge blood glucose (2hBG) [OR 0.697, 95% CI (0.581–0.837)], and FABP4 [OR 0.960, 95% CI (0.928–0.993)] at baseline were significant independent predictors of reversion from prediabetes to NGT. The area under the curve (AUC) value of the receiver operating characteristic curve for FABP4 was 0.605 (95% CI: 0.546–0.665), and the AUC for FABP4 combined with FBG and 2hBG was 0.716 (95% CI: 0.663–0.769). Conclusion A higher baseline level of FABP4 was positively correlated with an adverse profile of diabetes risk factors and negatively correlated with reversion from prediabetes to NGT. FABP4, FBG and 2hBG were predictors of reversion from prediabetes to NGT.