Preexposure effects of nicotine and acetaldehyde on conditioned taste aversion induced by both drugs
Preexposure effects of nicotine and acetaldehyde on conditioned taste aversion induced by both drugs
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DOI：
10.1016/s0091-3057(00)00284-7
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发表时间：
2000-08-01
影响因子：
3.6
通讯作者：
Amit, Z
中科院分区：
文献类型：
--
作者：
Kunin, D;Latendresse, MW;Amit, Z
先前的评估已经证明了在条件性味觉厌恶（CTA）范例中乙醇和尼古丁之间的相互作用。本研究评估了乙醇的主要强化代谢产物乙醛是否也会与尼古丁相互作用。在6项实验中，将缺水的雄性Wistar大鼠连续3天预先暴露于乙醛（0.2或0.3 g/kg，IP）或尼古丁（0.8、1.2或2 mg/kg，SC），然后在24 h后分别用尼古丁（0.8、1.2或2 mg/kg，SC）或乙醛（0.2或0.3 g/kg，IF）进行条件反射。有4个预处理日和4个无药试验日，每个间隔72小时。在考试日。动物可以在水和糖精之间自由选择。以下一组实验的结果证明了尼古丁和乙醛之间的剂量相关相互作用，其中较低剂量的每种药物未能减弱彼此诱导的CTA，但较高剂量的尼古丁（2 mg/kg）减弱了乙醛（0.3 g/kg）诱导的CTA形成。有人认为，乙醇的初级代谢产物可能在先前观察到的尼古丁和乙醇之间的相互作用中发挥作用。(C)2000 Elsevier Science Inc.
Previous assessments have demonstrated an interaction between ethanol and nicotine in the conditioned taste-aversion (CTA) paradigm. The present study assessed whether acetaldehyde, the primary reinforcing metabolite of ethanol, would interact with nicotine as well. In six experiments, water-deprived male Wistar rats were preexposed to either acetaldehyde (0.2 or 0.3 g/kg, IP) or nicotine (0.8, 1.2, or 2 mg/kg, SC) for 3 consecutive days and then subsequently conditioned, 24 h later, with either nicotine (0.8, 1.2, or 2 mg/kg, SC) or acetaldehyde (0.2 or 0.3 g/kg, IF), respectively. There were 4 conditioning days and 4 drug-free test days, each spaced 72 h apart. On test days. animals were offered a free choice between water and saccharin. The results of the following set of experiments demonstrated a dose-related interaction between nicotine and acetaldehyde, where lower doses of each drug failed to attenuate CTA induced by one another, but a higher nicotine dose (2 mg/kg) attenuated the formation of a CTA induced by acetaldehyde (0.3 g/kg). It was argued that the primary metabolite of ethanol may play a role in the interaction between nicotine and ethanol previously observed. (C) 2000 Elsevier Science Inc.