The role of microscopy in the investigation of paramyosin as a vaccine candidate against Schistosoma japonicum
The role of microscopy in the investigation of paramyosin as a vaccine candidate against Schistosoma japonicum
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DOI：
10.1016/s0169-4758(97)01205-2
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发表时间：
1998-03-01
期刊：
影响因子：
--
通讯作者：
Gobert, GN
中科院分区：
文献类型：
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作者：
Gobert, GN
副肌球蛋白作为抗血吸虫病疫苗的一种成分越来越受到人们的关注。免疫学和分子生物学技术在过去已经被用来研究副肌球蛋白疫苗作为抗溶酶体治疗的有效性。然而，最近的定位研究在超微结构和形态学水平上突出了一些问题的副肌球蛋白内寄生虫的作用。关于副肌球蛋白等非表面蛋白如何保护机体免受细菌感染的争论最近通过显微镜结果得到了解决。免疫定位研究表明副肌球蛋白在寄生虫中具有多种功能，并提供了疫苗如何靶向寄生虫的见解，如Geoffrey Gobert所讨论的。
There has been growing interest in paramyosin as a vaccine component to combat schistosomiasis. Immunological and molecular techniques have been used in the past to investigate the effectiveness of a paramyosin vaccine as an anti-schistosomal treatment. However, recent localization studies at ultrastructural and morphological levels have highlighted a number of questions concerning the role of paramyosin within schistosome parasites. Debates about how a non-surface protein such as paramyosin might provide protection against schistosome infections have recently been addressed by microscopy results. Immunolocalization studies have indicated multiple functions of paramyosin within the parasite and provided insights into how a vaccine may target the parasite, as discussed here by Geoffrey Gobert.