Abdominal fat radiodensity, quantity and cardiometabolic risk: The Multi-Ethnic Study of Atherosclerosis
Abdominal fat radiodensity, quantity and cardiometabolic risk: The Multi-Ethnic Study of Atherosclerosis
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DOI：
10.1016/j.numecd.2015.12.002
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发表时间：
2016-02-01
影响因子：
3.9
通讯作者：
Murthy, V. L.
中科院分区：
文献类型：
--
作者：
Shah, Ravi V.;Allison, M. A.;Murthy, V. L.
背景和目的：通过计算机断层扫描(CT)上的脂肪衰减来测量脂肪的放射性密度，已经成为一种潜在的“脂肪质量”的生物标志物。我们试图描述皮下、内脏和肌肉间脂肪的放射性密度和数量的关系，以及它在炎症、胰岛素抵抗和代谢综合征(METS)中的作用。方法和结果：我们研究了1511名来自动脉粥样硬化多种族研究的患者，他们接受了CT检查，以测量局部脂肪分布和放射性密度，以及生物标记物的评估和代谢综合征(METS)的判断。使用线性、Logistic和Cox回归分析来衡量脂肪放射性密度与(1)脂肪量、(2)心脏代谢功能障碍的生物标志物和(3)甲硫氨酸水平的流行和发病之间的关系。在每个脂肪储存库中，放射性密度与数量呈强烈的负相关(例如，内脏脂肪的放射性密度与数量：Rho=-0.82，P<；0.01)。在调整了年龄、性别和种族后，内脏脂肪放射密度降低与C反应蛋白、瘦素和胰岛素升高有关，但与脂联素降低有关(均为P<；0.01)。在完全调整心血管疾病危险因素后，内脏(而不是皮下或肌肉间)脂肪放射密度与METS的流行有关(OR=0.96，95%CI=0.93~0.99，P=0.01)。此外，调整后，较低的内脏脂肪放射性密度与METS的发生率相关(HR=0.95，95%CI为0.93~0.98，P<；0.01)。然而，在进一步调整内脏脂肪含量后，这种相关性变得不显著。结论：脂肪放射性密度与脂肪数量和相关炎症生物标志物密切相关。脂肪放射性密度(尤其是内脏脂肪)可能是心脏代谢风险的一个补充的、容易评估的标志。(C)2015年意大利糖尿病学会、意大利动脉粥样硬化研究学会、意大利人类营养学会和费德里科二世大学临床内外科。爱思唯尔出版，版权所有。
Background and aims: Fat radiodensity, as measured by fat attenuation on computed tomography (CT), has emerged as a potential biomarker of "fat quality." We sought to characterize the relationship between fat radiodensity and quantity in subcutaneous, visceral, and intermuscular fat depots, and its role in inflammation, insulin resistance, and metabolic syndrome (MetS).Methods and results: We studied 1511 individuals from the Multi-Ethnic Study of Atherosclerosis who underwent CT for measurement of regional fat distribution and radiodensity, along with biomarker assessments and adjudication of incident metabolic syndrome (MetS). Linear, logistic and Cox regression analyses were used to measure association between fat radiodensity and (1) fat quantity, (2) biomarkers of cardiometabolic dysfunction, and (3) both prevalent and incident MetS. In each fat depot, radiodensity was strongly and inversely associated with quantity (e. g., visceral fat radiodensity vs. quantity: rho = -0.82, P < 0.01). After adjustment for age, sex and race, lower visceral fat radiodensity was associated with greater C-reactive protein, leptin and insulin, but lower adiponectin (P < 0.01 for all). After full adjustment for cardiovascular disease risk factors, visceral (but not subcutaneous or intermuscular) fat radiodensity was associated with prevalent MetS (OR = 0.96, 95% CI = 0.93-0.99, P = 0.01). Moreover, lower visceral fat radiodensity was associated with incident MetS after the same adjustment (HR = 0.95, 95% CI 0.93-0.98, P < 0.01). However, this association became non-significant after further adjustment for visceral fat quantity.Conclusion: Fat radiodensity is strongly correlated with fat quantity and relevant inflammatory biomarkers. Fat radiodensity (especially for visceral fat) may be a complementary, easily assessed marker of cardiometabolic risk. (C) 2015 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.