Advances in radiotherapy for brain metastases.
Advances in radiotherapy for brain metastases.
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DOI：
10.1093/noajnl/vdab126
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Shih HA
中科院分区：
文献类型：
--
作者：
Gondi V;Meyer J;Shih HA
随着新型全身治疗提高了转移性癌症患者的生存率，脑转移的频率继续增加。多年来，管理战略不断演变。从历史上看，立体定向放射外科手术一直被用作全脑放射治疗（WBRT）的促进，但越来越多地被用作WBRT的替代品。鉴于其治疗脑中大转移和微转移的能力，WBRT多年来一直是一种重要的管理策略，最近的研究已经确定了更安全地提供WBRT的技术和药理学方法。在这篇综述中，我们概述了放射治疗方案的现状，并讨论了在当代脑转移瘤治疗中整合放射治疗进展的方法。
As novel systemic therapies yield improved survival in metastatic cancer patients, the frequency of brain metastases continues to increase. Over the years, management strategies have continued to evolve. Historically, stereotactic radiosurgery has been used as a boost to whole-brain radiotherapy (WBRT) but is increasingly being used as a replacement for WBRT. Given its capacity to treat both macro- and micro-metastases in the brain, WBRT has been an important management strategy for years, and recent research has identified technologic and pharmacologic approaches to delivering WBRT more safely. In this review, we outline the current landscape of radiotherapeutic treatment options and discuss approaches to integrating radiotherapy advances in the contemporary management of brain metastases.