INTERACTION BETWEEN CARDIAC RECEPTORS AND SINOAORTIC BARORECEPTORS IN THE CONTROL OF EFFERENT CARDIAC SYMPATHETIC-NERVE ACTIVITY DURING MYOCARDIAL ISCHEMIA IN DOGS
INTERACTION BETWEEN CARDIAC RECEPTORS AND SINOAORTIC BARORECEPTORS IN THE CONTROL OF EFFERENT CARDIAC SYMPATHETIC-NERVE ACTIVITY DURING MYOCARDIAL ISCHEMIA IN DOGS
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DOI：
10.1161/01.res.45.6.728
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发表时间：
1979-01-01
影响因子：
20.1
通讯作者：
THAMES, MD
中科院分区：
文献类型：
--
作者：
FELDER, RB;THAMES, MD
在冠状动脉阻塞期间，动脉压力感受器和心脏感受器与迷走神经传入对传出心脏交感神经活动的相对影响被确定。在短暂（90-s）回旋支（Cx）和前降支（LAD）冠状动脉闭塞期间，测定心率（次/min）、动脉压（mm Hg）和综合心脏交感神经活动（CSNA，相对于对照组的百分比变化;从左腹侧袢锁骨下动脉的切断中心端记录）的变化。在颈动脉和主动脉压力感受器完整的犬中，增加（平均值±。SE）在CSNA中Cx（7 . ±. 2%）和LAD（9 . ±.尽管在Cx期间动脉压下降显著更大（-14 . ±. 3 mm Hg）比LAD（-5 . ±. 2 mm Hg）冠状动脉闭塞。在这些闭塞期间，心率没有变化。在3只犬中，下腔静脉闭塞引起的低血压导致CSNA增加幅度大于LAD或Cx闭塞引起的动脉压降低幅度。在去窦主动脉神经的犬中，Cx冠状动脉闭塞导致CSNA降低（-14 . ±-. 4%）、动脉压（-38 . ±. 6 mm Hg）和心率（-13 . ±. 5次/分钟），而LAD闭塞导致动脉压的小幅降低（-12 ±-1.5次/分钟）。5 mm Hg），CSNA或心率无变化。迷走神经切断术消除了CSNA和心率的下降，并减弱了动脉压对Cx闭塞的反应。具有迷走神经传入的心脏感受器在心肌缺血期间，特别是在下后部缺血期间对心脏交感神经活动产生抑制性影响，并且这种影响限制了由缺血诱导的低血压引起的动脉压力感受器介导的CSNA增加。
The relative influence of arterial baroreceptors and of cardiac receptors with vagal afferents on efferent cardiac sympathetic nerve activity during coronary artery occlusion was determined. Changes in heart rate (beats/min), arterial pressure (mm Hg), and integrated cardiac sympathetic nerve activity (CSNA, percent change from control; recorded from the cut central end of the left ventral ansa subclavia) were determined during transient (90-s) circumflex (Cx) and anterior descending (LAD) coronary artery occlusions. In dogs with carotid and aortic baroreceptors intact, increases (mean .+-. SE) in CSNA during Cx (7 .+-. 2%) and LAD (9 .+-. 5%) occlusions were similar despite a significantly greater fall in arterial pressure during Cx (-14 .+-. 3 mm Hg) than during LAD (-5 .+-. 2 mm Hg) coronary artery occlusion. Heart rate did not change during these occlusions. In 3 dogs, hypotension induced by inferior vena caval occlusion resulted in greater increases in CSNA than did comparable decreases in arterial pressure resulting from occlusion of LAD or Cx. In dogs with sinoaortic denervation, Cx coronary occlusion resulted in decreases in CSNA (-14 .+-. 4%), arterial pressure (-38 .+-. 6 mm Hg), and heart rate (-13 .+-. 5 beats/min), whereas LAD occlusion resulted in a small decrease in arterial pressure (-12 .+-. 5 mm Hg) and no change in CSNA or heart rate. Vagotomy abolished the decreases in CSNA and heart rate and attenuated the arterial pressure responses to Cx occlusion. Cardiac receptors with vagal afferents exert an inhibitory influence on cardiac sympathetic nerve activity during myocardial ischemia, particularly during inferoposterior ischemia and this influence limits the arterial baroreceptor-mediated increases in CSNA resulting from ischemia-induced hypotension.