The solitary nucleus connectivity to key autonomic regions in humans
The solitary nucleus connectivity to key autonomic regions in humans
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DOI：
10.1111/ejn.15691
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发表时间：
2022-06-21
影响因子：
3.4
通讯作者：
Borsook, David
中科院分区：
文献类型：
--
作者：
Forstenpointner, Julia;Maallo, Anne Margarette S.;Borsook, David
孤束核(NTS)是一种关键的脑干结构，将感觉间的外周信息传递到相互关联的脑中心，以引起快速的自主反应，并形成长期的神经内分泌和运动模式。结构和功能NTS的连接性已经在实验动物中得到了广泛的研究。但关于NTS在人类中的连接体的信息有限。使用磁共振成像，我们检查了人类连接组项目中20名健康参与者的扩散和静息状态数据。通过对文献的系统回顾，选择了脑干(n=8)、皮质下(n=6)、小脑(n=2)和皮质(n=5)区域，并通过概率束成像以及功能性和方向性(即Granger因果关系)分析来评估它们之间的白质NTS联系。这项基础研究证实了之前动物模型的结果，并为NTS在人类中的整合提供了新的方面。我们可以总结出两个重要的发现：(1)NTS主要处理传入输入；(2)NTS加工的偏侧化主要集中在左侧。我们的结果为进一步研究NTS的三方作用奠定了基础，包括受体间的输入整合、由此产生的神经化学外流和认知/情感加工。这些数据的含义增加了对NTS在自主神经功能的特定方面的作用的理解。
The nucleus tractus solitarius (NTS) is a key brainstem structure relaying interoceptive peripheral information to the interrelated brain centres for eliciting rapid autonomic responses and for shaping longer-term neuroendocrine and motor patterns. Structural and functional NTS' connectivity has been extensively investigated in laboratory animals. But there is limited information about NTS' connectome in humans. Using MRI, we examined diffusion and resting state data from 20 healthy participants in the Human Connectome Project. The regions within the brainstem (n = 8), subcortical (n = 6), cerebellar (n = 2) and cortical (n = 5) parts of the brain were selected via a systematic review of the literature and their white matter NTS connections were evaluated via probabilistic tractography along with functional and directional (i.e. Granger causality) analyses. The underlying study confirms previous results from animal models and provides novel aspects on NTS integration in humans. Two key findings can be summarized: (1) the NTS predominantly processes afferent input and (2) a lateralization towards a predominantly left-sided NTS processing. Our results lay the foundations for future investigations into the NTS' tripartite role composed of interoreceptors' input integration, the resultant neurochemical outflow and cognitive/affective processing. The implications of these data add to the understanding of NTS' role in specific aspects of autonomic functions.