Evidence for Age-Dependent in Vivo Conformational Rearrangement within Aβ Amyloid Deposits
Evidence for Age-Dependent in Vivo Conformational Rearrangement within Aβ Amyloid Deposits
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DOI：
10.1021/cb4000376
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发表时间：
2013-06-01
影响因子：
4
通讯作者：
Nilsson, K. Peter R.
中科院分区：
文献类型：
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作者：
Nystrom, Sofie;Psonka-Antonczyk, Katarzyna M.;Nilsson, K. Peter R.
大脑中聚集的β肽沉积是阿尔茨海默病的主要标志之一。利用两种结构不同但相关的超敏感荧光淀粉样蛋白标记物LCOs的组合，报告了不同的超微结构元素，我们发现转基因小鼠模型随着动物年龄的增长，a β斑块内发生构象重排。这一重要的机制见解应该有助于设计和评估目前使用斑块负荷作为读数的实验。
Deposition of aggregated A beta peptide in the brain is one of the major hallmarks of Alzheimer's disease. Using a combination of two structurally different, but related, hypersensitive fluorescent amyloid markers, LCOs, reporting on separate ultrastructural elements, we show that conformational rearrangement occurs within A beta plaques of transgenic mouse models as the animals age. This important mechanistic insight should aid the design and evaluation of experiments currently using plaque load as readout.