Quantitative trait loci for fatty acid composition in longissimus dorsi and abdominal fat: results from a White Duroc x Erhualian intercross F2 population
Quantitative trait loci for fatty acid composition in longissimus dorsi and abdominal fat: results from a White Duroc x Erhualian intercross F2 population
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DOI：
10.1111/j.1365-2052.2008.01819.x
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发表时间：
2009-04-01
期刊：
影响因子：
2.4
通讯作者：
Huang, L.
中科院分区：
文献类型：
--
作者：
Guo, T.;Ren, J.;Huang, L.
对 660 头 F-2 动物（包括白杜洛克 x 二花莲杂交群体中的 250 头公猪和 410 头后备母猪）进行全基因组扫描，以检测背最长肌和腹部脂肪中脂肪酸组成的数量性状位点 (QTL)。所测性状共鉴定出 153 个 QTL，其中包括 63 个全基因组显着 QTL 和 90 个暗示效应。显着影响主要表现在猪染色体（SSC）4、7、8和X上。SSC3和11上没有检测到关联。总的来说，本研究检测到的QTL对最长肌和腹部脂肪的脂肪酸组成显示出明显的影响。腹部脂肪中脂肪酸组成的 QTL 与之前在背膘中鉴定的 QTL 不对应，并且肌肉脂肪酸组成的大部分 QTL 被映射到与以前研究不同的染色体区域。 SSC4 和 SSC7 上的两个区域对最长肌和腹部脂肪中的单不饱和脂肪酸 (MUFA) 和多不饱和脂肪酸 (PUFA) 显示出显着的多效性作用。另外两个对最长肌MUFA和PUFA具有显着多方面影响的QTL分别在SSC8和SSCX上发现。中国儿花莲等位基因与大多数检测到的 QTL 中 MUFA 与饱和脂肪酸的比例增加有关，显示出对人类健康的有益作用。
A whole-genome scan was performed on 660 F-2 animals including 250 barrows and 410 gilts in a White Duroc x Erhualian intercross population to detect quantitative trait loci (QTL) for fatty acid composition in the longissimus dorsi muscle and abdominal fat. A total of 153 QTL including 63 genome-wide significant QTL and 90 suggestive effects were identified for the traits measured. Significant effects were mainly evident on pig chromosomes (SSC) 4, 7, 8 and X. No association was detected on SSC3 and 11. In general, the QTL detected in this study showed distinct effects on fatty acid composition in the longissimus muscle and abdominal fat. The QTL for fatty acid composition in abdominal fat did not correspond to those identified previously in backfat and the majority of QTL for the muscle fatty acid composition were mapped to chromosomal regions different from previous studies. Two regions on SSC4 and SSC7 showed significant pleiotropic effects on monounsaturated (MUFA) and polyunsaturated fatty acid (PUFA) in both longissimus muscle and abdominal fat. Another two QTL with significant multi-faceted effects on MUFA and PUFA in the longissimus muscle were found each on SSC8 and SSCX. Chinese Erhualian alleles were associated with increased ratios of MUFA to saturated fatty acid at most of the QTL detected, showing beneficial effect in terms of human health.