DESIGN OF THE MAMMALIAN RESPIRATORY SYSTEM .7. SCALING MITOCHONDRIAL VOLUME IN SKELETAL-MUSCLE TO BODY-MASS
DESIGN OF THE MAMMALIAN RESPIRATORY SYSTEM .7. SCALING MITOCHONDRIAL VOLUME IN SKELETAL-MUSCLE TO BODY-MASS
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DOI：
10.1016/0034-5687(81)90079-7
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发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
WEIBEL, ER
中科院分区：
文献类型：
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作者：
MATHIEU, O;KRAUER, R;WEIBEL, ER
由于O2主要消耗在肌肉线粒体在重体力劳动，在骨骼肌中的线粒体的体积密度和最大O2摄取之间的关系将是预期的。线粒体的体积密度，VV（mt，f），分析了一系列非洲哺乳动物的4块肌肉，体重范围从0.4-251公斤。半腱肌、背最长肌、股内侧肌和膈肌的VV（mt，f）分别为Mb [体重]-0.231，Mb-0.163，Mb-0.139和Mb-0.055。隔膜的质量或体积按比例缩放为Mb 0.865。对于半腱肌和股内侧肌，肌肉体积（Vmu）分别标度为Mb 1.030和Mb 0.956。换算这些肌肉中线粒体的绝对体积Vmt（Vmt = Vv（mt.f）× Vv）。Vmu）对Mb给出了回归线，其斜率与VO 2 max [最大O2消耗率]对体重获得的斜率非常平行。这些肌肉中线粒体的体积与VO 2 max或VO 2 max的比率与体重无关。
Since O2 is mainly consumed in muscle mitochondria during heavy physical work, a relationship between the volume density of mitochondria in skeletal muscles and maximal O2 uptake would be expected. The volume density of mitochondria, Vv(mt, f), was analyzed in 4 muscles of a series of African mammals ranging in body mass from 0.4-251 kg. Vv(mt,f) was scaled as Mb [body mass] -0.231, Mb-0.163, Mb-0.139 and Mb-0.055 in Mm. [musculus] semitendinosus, longissimus dorsi, vastus medialis and diaphragm, respectively. The mass or volume of diaphragm scaled as Mb0.865. For Mm. semitendinosus and vastus medialis, muscle volume (Vmu) scaled as Mb1.030 and Mb0.956, respectively. Scaling the absolute volume of mitochondria Vmt in these muscles (Vmt = Vv(mt.f) .times. Vmu) against Mb gives regression lines whose slopes closely parallel that obtained for .ovrhdot.VO2 max [maximal O2 consumption rate] against body mass. The ratio of volume of mitochondria in these muscles to .ovrhdot.VO2 max is body mass independent.