A Case of Multiple Sclerosis with Homonymous Hemianopia Examined by Positron Emission Tomography
A Case of Multiple Sclerosis with Homonymous Hemianopia Examined by Positron Emission Tomography
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正电子发射断层扫描多发性硬化症同向偏盲一例
DOI：
10.1007/s10384-004-0128-1
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发表时间：
2004
影响因子：
2.4
通讯作者：
T. Akashi
中科院分区：
文献类型：
--
作者：
Hideki Murai;M. Kiyosawa;Yukihisa Suzuki;Shoichi Mizoguchi;K. Ishii;K. Ishikawa;T. Akashi
为了证明正电子发射断层扫描(PET)检查患有偏盲的多发性硬化症(MS)患者的有效性。病例：一位20岁的男性患者就诊时主诉左偏盲和头痛。观察患者的视力为1.2(N.C.)OD和0.9(1.0)操作系统。磁共振成像(MRI)显示在颞顶叶有一个肿块。脑活检病理诊断为多发性硬化症。18F-氟代脱氧葡萄糖正电子发射计算机断层扫描显示病变部位和视皮层的葡萄糖代谢明显降低。含11C-氟马西尼的PET显示脱髓鞘的视神经辐射的11C摄取减少，而初级视皮层的11C摄取仅轻微减少。~(11)C-氟马西尼PET结果显示神经元密度略有降低。结论PET可作为评估MS偏盲患者视力预后的有用工具.日本眼科杂志，2004年；48：591-593；日本眼科学会，2004
BackgroundTo demonstrate the efficacy of positron emission tomography (PET) for examining multiple sclerosis (MS) patients with hemianopia.CaseA 20-year-old man visited us with a complaint of left homonymous hemianopia and headache.ObservationsThe patient’s visual acuity was 1.2 (n.c.) OD and 0.9 (1.0) OS. Magnetic resonance imaging (MRI) showed a mass in the temporoparietal lobe. A pathological diagnosis of MS was made by brain biopsy. Low glucose metabolism in the lesion and visual cortex was observed by PET with18F-fluorodeoxy glucose. PET with11C-flumazenyl revealed a reduction of11C-uptake in the demyelinated optic radiation, and only a slight reduction of11C-uptake in the primary visual cortex. The results of11C-flumazenyl PET suggested a slight reduction of neuronal density. In 2 years, the visual field recovered to the normal state.ConclusionPET can be a useful tool for estimating the visual outcome of patients with hemianopia in MS.Jpn J Ophthalmol2004;48:591–593 © Japanese Ophthalmological Society 2004