Interaction of curcumin with Zn(II) and Cu(II) ions based on experiment and theoretical calculation
Interaction of curcumin with Zn(II) and Cu(II) ions based on experiment and theoretical calculation
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基于实验和理论计算的姜黄素与 Zn(II) 和 Cu(II) 离子的相互作用
DOI：
10.1016/j.molstruc.2010.09.049
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发表时间：
2010-12-15
影响因子：
3.8
通讯作者：
Zhou, Ping
中科院分区：
文献类型：
--
作者：
Zhao, Xue-Zhou;Jiang, Teng;Zhou, Ping
Curcumin and its complexes with Zn2+ and Cu2+ ions were synthesized and characterized by elemental analysis, mass spectroscopy, IR spectroscopy, UV spectroscopy, solution H-1 and solid-state C-13 NMR spectroscopy, EPR spectroscopy. In addition, the density functional theory (DFT)-based UV and C-13 chemical shift calculations were also performed to view insight into those compound structures and properties. The results show that curcumin easily chelate the metal ions, such as Zn2+ and Cu2+, and the Cu(II)-curcumin complex has an ability to scavenge free-radicals. We demonstrated the differences between Zn(II)-curcumin and Cu(II)-curcumin complexes in structure and properties, enhancing the comprehensions about the curcumin roles in the Alzhermer's disease treatment. (C) 2010 Elsevier B.V. All rights reserved.
