Role of IGF-I signaling in muscle bone interactions.
Role of IGF-I signaling in muscle bone interactions.
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DOI：
10.1016/j.bone.2015.04.036
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发表时间：
2015-11
期刊：
影响因子：
4.1
通讯作者：
Barton ER
中科院分区：
文献类型：
--
作者：
Bikle DD;Tahimic C;Chang W;Wang Y;Philippou A;Barton ER
骨骼肌和骨骼依赖于许多生长因子来进行发育、调节生长和维持生理强度。在这些行动中的一个主要参与者是胰岛素样生长因子I（IGF-I）。然而，由于这种生长因子可以直接增强肌肉质量和骨密度，因此它通过这两个器官系统之间的机械串扰间接改变了肌肉骨骼系统的状态。因此，IGF-I明显具有协同作用，其作用超出了通过其受体的直接活性。本综述将涵盖IGF-I的产生和信号传导，因为它涉及肌肉和骨骼，IGF-I活性产生的化学和机械影响，以及基于IGF-I的治疗策略的潜力。
Skeletal muscle and bone rely on a number of growth factors to undergo development, modulate growth, and maintain physiological strength. A major player in these actions is insulin-like growth factor I (IGF-I). However, because this growth factor can directly enhance muscle mass and bone density, it alters the state of the musculoskeletal system indirectly through mechanical crosstalk between these two organ systems. Thus, there are clearly synergistic actions of IGF-I that extend beyond the direct activity through its receptor. This review will cover the production and signaling of IGF-I as it pertains to muscle and bone, the chemical and mechanical influences that arise from IGF-I activity, and the potential for therapeutic strategies based on IGF-I.