Distinct Regions of Right Temporal Cortex Are Associated with Biological and Human-Agent Motion: Functional Magnetic Resonance Imaging and Neuropsychological Evidence
Distinct Regions of Right Temporal Cortex Are Associated with Biological and Human-Agent Motion: Functional Magnetic Resonance Imaging and Neuropsychological Evidence
复制标题
右颞叶皮层的不同区域与生物和人类主体运动相关：功能磁共振成像和神经心理学证据
DOI：
10.1523/jneurosci.5868-12.2013
复制
发表时间：
2013-09-25
影响因子：
5.3
通讯作者：
Caramazza, Alfonso
中科院分区：
文献类型：
--
作者：
Han, Zaizhu;Bi, Yanchao;Caramazza, Alfonso
在人类外侧颞叶皮层中，某些区域对人体运动表现出特定的敏感性。在这里，我们研究这种影响是否反映了一般的生物-非生物组织原则或特定的人类代理处理的过程进行比较处理的人，动物和工具运动的功能性磁共振成像（fMRI）实验与健康的参与者和基于体素的病变-症状映射（VLSM）研究的脑损伤患者（77中风患者）。功能磁共振成像实验表明，在颞叶外侧皮层，后上级颞沟对人和动物的运动表现出偏好，而右侧上级颞沟/回（mSTS/STG）的中部对人和功能性工具的运动表现出偏好。VLSM分析还显示，该右侧mSTS/STG区域的损伤导致人类和功能工具运动相对于动物运动的识别更严重的损伤，表明该脑区在人类运动处理中的因果作用。右mSTS/STG的研究结果不能被减少到一个偏好的关节运动或处理的社会变量，因为这两个因素都不涉及功能工具的运动识别。我们的结论是，一个一维的生物-非生物的区别不能完全解释视觉运动的影响，在外侧颞叶皮层。相反，结果表明右后颞叶皮质和mSTS/STG中存在分别与生物运动和人类智能体运动处理相关的不同成分。
In human lateral temporal cortex, some regions show specific sensitivity to human motion. Here we examine whether such effects reflect a general biological-nonbiological organizational principle or a process specific to human-agent processing by comparing processing of human, animal, and tool motion in a functional magnetic resonance imaging (fMRI) experiment with healthy participants and a voxelbased lesion-symptom mapping (VLSM) study of patients with brain damage (77 stroke patients). The fMRI experiment revealed that in the lateral temporal cortex, the posterior superior temporal sulcus shows a preference for human and animal motion, whereas the middle part of the right superior temporal sulcus/gyrus (mSTS/STG) shows a preference for human and functional tool motion. VLSM analyses also revealed that damage to this right mSTS/STG region led to more severe impairment in the recognition of human and functional tool motion relative to animal motion, indicating the causal role of this brain area in human-agent motion processing. The findings for the right mSTS/STG cannot be reduced to a preference for articulated motion or processing of social variables since neither factor is involved in functional tool motion recognition. We conclude that a unidimensional biological-nonbiological distinction cannot fully explain the visual motion effects in lateral temporal cortex. Instead, the results suggest the existence of distinct components in right posterior temporal cortex and mSTS/STG that are associated, respectively, with biological motion and human-agent motion processing.