The mouse homolog of the human amyloid beta protein (AD-AP) gene is located on the distal end of mouse chromosome 16: further extension of the homology between human chromosome 21 and mouse chromosome 16.
The mouse homolog of the human amyloid beta protein (AD-AP) gene is located on the distal end of mouse chromosome 16: further extension of the homology between human chromosome 21 and mouse chromosome 16.
复制标题
人类β淀粉样蛋白（AD-AP）基因的小鼠同源物位于小鼠16号染色体的远端：进一步延伸了人类21号染色体和小鼠16号染色体之间的同源性。
DOI：
10.1016/s0006-291x(87)80073-6
复制
发表时间：
1987
影响因子：
3.1
通讯作者：
Epstein,CJ
中科院分区：
文献类型：
--
作者：
Lovett,M;Goldgaber,D;Ashley,P;Cox,DR;Gajdusek,DC;Epstein,CJ
人淀粉样β蛋白是阿尔茨海默病中发现的脑淀粉样斑块的主要成分。编码这种蛋白质的基因位于21号染色体上，患有唐氏综合征（21三体）的个体也表现出阿尔茨海默病的早期发作形式。我们已经使用克隆的人淀粉样β蛋白基因和一组体细胞杂交体来定位该基因的小鼠同源物。我们在这里报告说，小鼠基因位于16号染色体16C3ter区域内，与人类21号染色体唐氏综合征区域内的其他三个基因相同。
The human amyloid β protein is the major constituent of the brain amyloid plaques found in Alzheimer disease. The gene that encodes this protein is located on chromosome 21, and individuals with Down syndrome (trisomy 21) also exhibit an early onset form of Alzheimer disease. We have used the cloned human amyloid β protein gene and a panel of somatic cell hybrids to map the location of the mouse homolog of this gene. We report here that the mouse gene is located on chromosome 16 within the region 16C3ter, in common with three other genes which map within the Down syndrome region of human chromosome 21.