Role of endocrine and paracrine factors in the adaptation of bone to mechanical loading.
Role of endocrine and paracrine factors in the adaptation of bone to mechanical loading.
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DOI：
10.1007/s11914-011-0050-7
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发表时间：
2011-06-01
影响因子：
4.3
通讯作者：
Lanyon, Lance E
中科院分区：
文献类型：
--
作者：
Price, Joanna S;Sugiyama, Toshihiro;Lanyon, Lance E
似乎没有独特的机械敏感途径，通过改变骨负荷调节骨量和结构，以确保足够的结构强度。相反，骨细胞中菌株衍生的变化激活了许多非特异性菌株敏感途径（包括钙通量、前列腺素、一氧化氮、细胞外信号调节激酶和硬化蛋白），这些途径的活性受到许多因素（包括雌激素受体）的修饰，因此这种贡献是辅助其他目的的。由这些因子修饰的菌株敏感通路与许多其他通路相互作用，其中一些通路似乎具有特定的骨调节潜力（如甲状旁腺激素通路），而其他通路如Wnt通路似乎主要与增殖、分化和凋亡的反应机制相关。这些多重相互作用的结果是刺激局部骨形成、吸收或维持现状，以维持现有的骨结构或使其适应新的机械方案。
There appears to be no unique mechanically sensitive pathway by which changes in bone loading regulate bone mass and architecture to ensure adequate structural strength. Rather, strain-derived changes in bone cells activate a number of nonspecific strain-sensitive pathways (including calcium fluxes, prostanoids, nitric oxide, extracellular signal-regulated kinase, and sclerostin), the activities of which are modified by a number of factors (including estrogen receptors) for which this contribution is subsidiary to other purposes. The strain-sensitive pathways modified by these factors interact with a number of other pathways, some of which appear to have specific osteoregulatory potential (eg, the parathyroid hormone pathway), whereas others such as the Wnt pathway appear to be associated primarily with the response mechanisms of proliferation, differentiation, and apoptosis. The outcome of these multiple interactions are stimuli for local bone formation, resorption, or maintenance of the status quo, to maintain existing bone architecture or adapt it to a new mechanical regimen.