Plasticity in gastrointestinal morphology and enzyme activity in lactating striped hamsters (Cricetulus barabensis)
Plasticity in gastrointestinal morphology and enzyme activity in lactating striped hamsters (Cricetulus barabensis)
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哺乳期条纹仓鼠（Cricetulus barabensis）胃肠道形态的可塑性和酶活性
DOI：
10.1242/jeb.138396
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发表时间：
2016-05
期刊：
影响因子：
--
通讯作者：
Zhao ZJ
中科院分区：
文献类型：
--
作者：
Zhao XY;Wen J;Tan S;Zhao ZJ
摘要 在小型哺乳动物中，消化生理学的显着表型可塑性已被证明使它们更容易应对精力充沛的时期，例如哺乳期。有人提出，肠道消化和吸收食物的能力并不是泌乳高峰期间持续能量摄入（SusEI）的限制因素。在这项研究中，研究了条纹仓鼠在不同繁殖阶段和饲养不同大小窝时的能量摄入和胃肠道形态的可塑性。还检查了与支撑可塑性的消化酶和神经内分泌激素相关的机制。与非生产期和泌乳后期相比，女性在泌乳高峰期的能量摄入、消化率、消化道质量以及胃蛋白酶和小肠麦芽糖酶、蔗糖酶和氨肽酶的活性显着增加。此外，与哺乳小窝和中窝的雌性相比，饲养大窝的雌性显着增加了能量摄入、消化率、胃肠质量和消化酶的活性，并且断奶的后代较重，这表明消化生理的显着可塑性提高了繁殖性能。相对于饲养小窝的雌性，饲养大窝的雌性下丘脑中刺豚鼠相关蛋白（AgRP） mRNA 的表达显着上调。血清瘦素水平以及下丘脑神经肽 Y (NPY) 和厌食神经肽阿片黑皮质素原 (POMC) 以及可卡因和安非他明调节转录物 (CART) 的 mRNA 表达在小、中和大窝雌性中没有差异。哺乳期的瘦素水平可能仅反映能量平衡状态，而不是食欲亢进的主要驱动因素。一些下丘脑神经肽，如 NPY、POMC 和 CART，可能与哺乳期间 SusEI 的限制有关。摘要：哺乳期条纹仓鼠在消化道形态和酶活性方面表现出显着的可塑性，从而提高了繁殖性能。
ABSTRACT In small mammals, marked phenotypic plasticity of digestive physiology has been shown to make it easier for them to cope with energetically stressful periods, such as lactation. It has been proposed that the capacity of the gut to digest and absorb food is not the limiting factor to sustained energy intake (SusEI) during peak lactation. In this study, plasticity in energy intake and gastrointestinal morphology was examined in striped hamsters at different stages of reproduction and when raising litters of different sizes. Mechanisms associated with digestive enzymes and neuroendocrine hormones underpinning the plasticity were also examined. Females significantly increased energy intake, digestibility, digestive tract mass and the activity of stomach pepsin and small intestine maltase, sucrase and aminopeptidase in peak lactation compared with the non-productive and post-lactating periods. Further, females raising large litters significantly increased energy intake, digestibility, gastrointestinal mass and activity of digestive enzymes, and weaned heavier offspring compared with those nursing small and medium litters, indicating that the significant plasticity of digestive physiology increased reproductive performance. Agouti-related protein (AgRP) mRNA expression in the hypothalamus was up-regulated significantly in females raising large litters relative to those raising small litters. Serum leptin levels, and mRNA expression of hypothalamus neuropeptide Y (NPY) and the anorexigenic neuropeptides pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) did not differ among females raising small, medium and large litters. Leptin levels in lactation may only reflect a state of energy balance rather than being the prime driver of hyperphagia. Some hypothalamic neuropeptides, such as NPY, POMC and CART, may be involved in the limits to the SusEI during lactation. Summary: Lactating striped hamsters show significant plasticity in digestive tract morphology and enzyme activity, which increases reproductive performance.
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DOI：
10.1242/jeb.022640
发表时间：
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期刊：
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影响因子：
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作者：
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