Early life adversity influences stress response association with smoking relapse
Early life adversity influences stress response association with smoking relapse
复制标题
DOI：
10.1007/s00213-017-4724-4
复制
发表时间：
2017-11-01
影响因子：
3.4
通讯作者：
Allen, Sharon
中科院分区：
文献类型：
--
作者：
al'Absi, Mustafa;Lemieux, Andrine;Allen, Sharon
我们检验了这样一种假设，即吸烟者中与压力相关的皮质醇钝化在那些有严重生活逆境史的人中尤为明显。本研究的两个目的是首先检查随意吸烟期间和戒烟后24小时内经历或高或低程度逆境的吸烟者的激素，渴望和戒断症状。其次，我们试图研究逆境与下丘脑-垂体-肾上腺（HPA）激素之间的关系，以预测戒烟尝试的第一个月复发。研究收集了103名吸烟者（49名女性）在随意吸烟期间和戒烟24小时后的激素和自我报告测量数据。在基线休息和两种情况下的急性应激反应中测量HPA激素。所有吸烟者都对戒烟感兴趣，我们前瞻性地使用压力反应测量来预测戒烟尝试的前4周内的复发。结果表明，高逆境与高痛苦和吸烟戒断症状相关。高水平的早期生活逆境与HPA活性升高有关，这在唾液和血浆皮质醇中都被发现。促肾上腺皮质激素（ACTH）应激反应在高逆境中明显增强，而在低逆境中不明显。本研究表明，早期生活逆境与压力相关的HPA反应有关。该研究还表明，在经历了高水平生活逆境的吸烟者中，ACTH和皮质醇反应的升高与吸烟复发的风险增加有关。
We examined the hypothesis that stress-related blunting of cortisol in smokers is particularly pronounced in those with a history of severe life adversity.The two aims of this study were first to examine hormonal, craving, and withdrawal symptoms during ad libitum smoking and after the first 24 h of abstinence in smokers who experienced high or low levels of adversity. Second, we sought to examine the relationship between adversity and hypothalamic-pituitary-adrenal (HPA) hormones to predict relapse during the first month of a smoking cessation attempt.Hormonal and self-report measures were collected from 103 smokers (49 women) during ad libitum smoking and after the first 24 h of abstinence. HPA hormones were measured during baseline rest and in response to acute stress in both conditions. All smokers were interested in smoking cessation, and we prospectively used stress response measures to predict relapse during the first 4 weeks of the smoking cessation attempt.The results showed that high adversity was associated with higher distress and smoking withdrawal symptoms. High level of early life adversity was associated with elevated HPA activity, which was found in both salivary and plasma cortisol. Enhanced adrenocorticotropic hormone (ACTH) stress response was evident in high-adversity but not in low-adversity relapsers.This study demonstrated that early life adversity is associated with stress-related HPA responses. The study also demonstrated that, among smokers who experienced a high level of life adversity, heightened ACTH and cortisol responses were linked with increased risk for smoking relapse.