Diabetic effects on microchambers and macrochambers tissue properties in human heel pads
Diabetic effects on microchambers and macrochambers tissue properties in human heel pads
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DOI：
10.1016/j.clinbiomech.2009.06.005
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发表时间：
2009-10-01
影响因子：
1.8
通讯作者：
Lin, Shih-Chieh
中科院分区：
文献类型：
--
作者：
Hsu, Chih-Chin;Tsai, Wen-Chung;Lin, Shih-Chieh
背景资料：本研究试图突出2型糖尿病患者和年龄匹配的健康志愿者之间微腔和大腔机械性能的差异。18名糖尿病患者的29个足跟和16名年龄匹配的健康参与者的28个足跟通过由10 MHz紧凑型线性阵列超声换能器、有机玻璃圆柱体、和测压元件。两组受试者的平均年龄约为55岁，体重指数约为25 kg/m（2）。使用步进电机以6 mm/s的速度将传感器逐渐加载到测试足跟上，从零到最大应力78 kPa。结果：糖尿病患者微腔室应变显著大于健康人（0.291（SD 0.14）vs.0.104（SD 0.057）; P < 0.001）;糖尿病患者的Macrochambers应变显著低于健康受试者（0.355（SD 0.098）vs. 0.450（SD 0.092）; P=0.001）。糖尿病患者微室刚度显著低于健康人（393（SD 371）kPa vs.1140（SD 931）kPa; P < 0.001）。糖尿病患者的宏室硬度显著大于健康人（239（SD 77）kPa vs. 181（SD 42）kPa; P = 0.001）。解释：糖尿病患者的足跟垫组织特性发生不均匀改变。增加宏室，但减少微室刚度可能会导致减少缓冲能力糖尿病脚跟。(C)2009爱思唯尔有限公司保留所有权利。
Background: The study attempted to highlight the differences of mechanical properties in microchambers and macrochambers between patients with type 2 diabetes mellitus and age-matched healthy volunteers.Methods: A total of 29 heels in 18 diabetic patients and 28 heels in 16 age-matched healthy participants were examined by a loading device consisting of a 10-MHz compact linear-array ultrasound transducer, a Plexiglas cylinder, and a load cell. Subjects in both groups were on average about 55 years old with a body mass index of approximately 25 kg/m(2). A stepping motor was used to progressively load the transducer on the tested heels at a velocity of 6 mm/s from zero to the maximum stress of 78 kPa. Unloaded thickness, strain, and elastic modulus in microchambers, macrochambers and heel pads were measured.Findings: Microchambers strain in diabetic patients was significantly greater than that in healthy subjects (0.291 (SD 0.14) vs. 0.104 (SD 0.057); P < 0.001). Macrochambers strain in diabetic patients was significantly less than that in healthy subjects (0.355 (SD 0.098) vs. 0.450 (SD 0.092); P=0.001). Microchambers stiffness in diabetic patients was significantly less than that in healthy persons (393 (SD 371) kPa vs. 1140 (SD 931) kPa; P < 0.001). Macrochambers stiffness in diabetic patients was significantly greater than that in healthy persons (239 (SD 77) kPa vs. 181 (SD 42) kPa; P = 0.001).Interpretation: Heel pad tissue properties are altered heterogeneously in people with diabetes. Increased macrochambers but decreased microchambers stiffness may cause diminished cushioning capacities in diabetic heels. (C) 2009 Elsevier Ltd. All rights reserved.