Phylogenetic profiling of protein interaction networks in eukaryotic transcription factors reveals focal proteins being ancestral to hubs
Phylogenetic profiling of protein interaction networks in eukaryotic transcription factors reveals focal proteins being ancestral to hubs
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DOI：
10.1016/j.gene.2004.12.031
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发表时间：
2005-03-14
期刊：
影响因子：
3.5
通讯作者：
Bornberg-Bauer, E
中科院分区：
文献类型：
--
作者：
Amoutzias, GD;Weiner, J;Bornberg-Bauer, E
基因组学、蛋白质组学和其他数据的结合，使得能够重建复杂细胞单位的进化，从而超越传统分子生物学的还原论观点。然而，迄今为止，大多数试图研究蛋白质相互作用网络演化的模型都是基于对它们的全局统计特性的分析，如它们的无标度行为。我们已经调查了三个古老的真核转录因子家族的相互作用，其中相当可靠的数据是可用的。对于所有三个家庭，bZIP，bHLH和NR（核受体），我们发现，同源二聚化蛋白质可能是祖先和一系列的单基因重复，结合域referencents，在建立基本的网络架构的主要驱动力。然而，整体的缩放行为并不总是精确地赋予一些理论模型的网络演化。总之，需要开发反映分子进化的生物学细节的新模型。(c)2004 Elsevier B.V.保留所有权利。
The combination of genomic, proteomic and other data, enables to reconstruct the evolution of complex cellular units thus transcending the more reductionistic view of traditional molecular phylogeny. However, most models which try to investigate the evolution of protein interaction networks so far are based on the analysis of their global statistical properties, Such as their scale-free behaviour. We have investigated phylogenies of three families of ancient eukaryotic transcription factors for which fairly reliable interaction data are available. For all three families, bZIP, bHLH and NR (nuclear receptors), we find that homo-dimerising proteins were probably the ancestors and that series of single gene duplications, in combination with domain-rearrangernents, were the main driving force in establishing the basic network architecture. However, the overall scaling behaviour does not always precisely confer to some theoretical models on network evolution. In conclusion, new models which reflect the biological details of molecular evolution, need to be developed. (c) 2004 Elsevier B.V. All rights reserved.