Changes in collagen metabolism in prostate cancer: A host response that may alter progression
Changes in collagen metabolism in prostate cancer: A host response that may alter progression
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DOI：
10.1016/s0022-5347(05)65656-x
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发表时间：
2001-11-01
影响因子：
6.6
通讯作者：
Bailey, AJ
中科院分区：
文献类型：
--
作者：
Burns-Cox, N;Avery, NC;Bailey, AJ
目的：癌细胞与细胞外基质的相互作用对癌症的进展至关重要。然而，关于癌症对胶原代谢的影响知之甚少，胶原是细胞外基质的主要成分。我们研究了前列腺癌中胶原代谢的变化与Gleason评分的增加，并与临床参数和患者survival.Materials和方法：胶原含量和临床参数在3种类型的前列腺组织进行了比较，包括前列腺癌的病灶，未受影响的组织从同一个癌前列腺和前列腺组织的患者没有癌症的证据。此外，为了评估胶原代谢，对45例接受前列腺活检的患者前瞻性获得的组织进行了胶原含量、胶原交联的类型和程度、丝氨酸蛋白酶、基质金属蛋白酶和I型胶原的C末端前肽的评估。随着格里森的增加，病灶处的癌胶原蛋白含量的总和降低，而来自同一前列腺的周围未受影响的组织的放射性增加到显著高于来自没有癌症的对照的水平。前列腺活检材料中的胶原蛋白合成的标记物显着增加，在存在的前列腺癌。结论：在前列腺癌中有胶原代谢的变化，不仅在癌灶，但也在附近的组织学良性前列腺组织。这些观察到的变化与肿瘤的Gleason评分相关，可能代表宿主反应。周围未受影响的组织中的胶原蛋白含量可能是患者存活的预测因子。
Purpose: The interaction of cancer cells and the extracellular matrix is essential for cancer progression. However, little is known about the influence of cancer on the metabolism of collagen, which is the major constituent of the extracellular matrix. We studied changes in collagen metabolism in prostate cancer with increasing Gleason score and correlated them with clinical parameters and patient survival.Materials and Methods: Collagen content and clinical parameters in 3 types of prostatic tissue were compared, including the foci of prostatic cancer, unaffected tissue from the same cancerous prostates and prostatic tissue from patients with no evidence of cancer. In addition, to assess collagen metabolism tissue obtained prospectively from 45 patients undergoing prostatic biopsy was assessed for collagen content, the type and extent of collagen cross-linking, serine proteinase, matrix metalloproteinase and the C-terminal propeptide of type I collagen.Results: With increasing Gleason sum of the cancer collagen content at the focus decreased, while that of surrounding unaffected tissue from the same prostate increased to levels significantly above that from controls with no cancer. Markers of collagen synthesis in the prostate biopsy material were significantly increased in the presence of prostate cancer.Conclusions: In prostate cancer there are changes in collagen metabolism not only in the cancer focus but also in nearby histologically benign prostatic tissue. These observed changes are related to the Gleason score of the tumor and may represent a host response. Collagen content in the surrounding unaffected tissue may be a predictor of patient survival.