Reversible Immunocontraception in mate monkeys immunized with Eppin
Reversible Immunocontraception in mate monkeys immunized with Eppin
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DOI：
10.1126/science.1099743
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发表时间：
2004-11-12
期刊：
影响因子：
56.9
通讯作者：
Rao, AJ
中科院分区：
文献类型：
--
作者：
O'Rand, MG;Widgren, EE;Rao, AJ
为妇女制定了各种形式的节育措施，但目前男子的选择很少。有效、安全和可逆的配偶避孕药的开发是全世界计划生育所期望的。我们现在报告避孕的配偶非人灵长类动物（猕猴辐射）免疫Eppin，睾丸/附睾特异性蛋白。9只猴子中有7只（78%）对Eppin产生了高滴度，这些高滴度的猴子中有一只是不育的。当免疫停止时，七分之五（71%）的高抗Eppin滴度配偶恢复生育能力。这项研究表明，有效和可逆的配偶免疫避孕是一个可以实现的目标。这种免疫避孕方法可以扩展到人类。
Various forms of birth control have been developed for women; however, there are currently few options for men. The development of mate contraceptives that are effective, safe, and reversible is desired for family planning throughout the world. We now report contraception of mate nonhuman primates (Macaca radiata) immunized with Eppin, a testis/epididymis-specific protein. Seven out of nine mates (78%) developed high titers to Eppin, and A of these high-titer monkeys were infertile. Five out of seven (71%) high-anti-Eppin titer mates recovered fertility when immunization was stopped. This study demonstrates that effective and reversible mate immunocontraception is an attainable goal. This method of immunocontraception may be extended to humans.